Evidence map›Paper›PMID 39514307›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A conserved mechanism couples cytosolic domain movements to pore gating in the TRPM2 channel.

Balázs Tóth, Yuefeng Jiang, Andras Szollosi, Zhe Zhang, László Csanády

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Balázs Tóth *Department of Biochemistry, Semmelweis University, Budapest H-1094, Hungary.
Yuefeng Jiang *State Key Laboratory of Membrane Biology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.ORCID 0000-0003-3985-2027
Andras SzollosiDepartment of Biochemistry, Semmelweis University, Budapest H-1094, Hungary.ORCID 0000-0002-5570-4609
Zhe ZhangState Key Laboratory of Membrane Biology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.ORCID 0000-0002-4932-4343
László CsanádyDepartment of Biochemistry, Semmelweis University, Budapest H-1094, Hungary.ORCID 0000-0002-6547-5889

Funding

EU Horizon 2020 Research and Innovation Program 739593Hungarian Academy of Sciences Bolyai Research Scholarship BO/00685/22Ministry of Human Capacities of Hungary ÚNKP-23-5-SE-21MOST | National Key Research and Development Program of China (NKPs) 2021YFA1302300MOST | National Natural Science Foundation of China (NSFC) 32171201Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (NKFI) FK-138576Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (NKFI) KKP_22 144199
6 · The paper itself

Abstract

Transient Receptor Potential Melastatin 2 (TRPM2) cation channels contribute to immunocyte activation, insulin secretion, and central thermoregulation. TRPM2 opens upon binding cytosolic Ca

Indexed as

CalciumCryoelectron MicroscopyIon Channel GatingTRPM Cation ChannelsAdenosine Diphosphate RiboseAnimalsCytosolHumansModels, MolecularProtein BindingProtein DomainsSea AnemonesAdenosine Diphosphate RiboseCalciumTRPM Cation Channelsconformational changecryo-EMgating mechanisminside-out patch-clampTRP channel

Identifiers

PMID39514307
PMCPMC11573590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.