Evidence map›Paper›PMID 39514305›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Light-sensitive Ca

Ahmed M Eltanahy, Alex Aupetit, Ethan D Buhr, Russell N Van Gelder, Albert L Gonzales

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Acute Ocular Effects of Violet and Red Light Exposure in Young Adults.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  3. Skin capillary endothelial cells form a network of spatiotemporally conserved CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Light-sensitive CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ahmed M EltanahyDepartment of Physiology and Cell Biology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318.ORCID 0000-0002-1351-9261
Alex AupetitDepartment of Physiology and Cell Biology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318.
Ethan D BuhrDepartment of Ophthalmology, University of Washington, Seattle, WA 98104.
Russell N Van GelderDepartment of Ophthalmology, University of Washington, Seattle, WA 98104.
Albert L GonzalesDepartment of Physiology and Cell Biology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318.ORCID 0000-0002-5382-8712

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI ROBERT D HARVEY · 2019 to 2026
$20.3M
Amyloid-β Disruption of Pericyte Control of Capillary HemodynamicsR01AG081935 · NIA · UNIVERSITY OF NEVADA RENO · PI Albert Louis Gonzales · 2023 to 2026
$2.0M
Pericyte Control of Junctional Blood FlowK01HL138215 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI GONZALES, ALBERT LOUIS · 2017 to 2021
$744k
BrightFocus Foundation (BFF) M2022010NHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K01HL138215HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM130459HHS | NIH | National Institute on Aging (NIA) R01AG081935NHLBI NIH HHS K01 HL138215NIA NIH HHS R01 AG081935NIGMS NIH HHS P20 GM130459Research to Prevent Blindness (RPB) 0000
6 · The paper itself

Abstract

The choroid is the thin, vasculature-filled layer of the eye situated between the sclera and the retina, where it serves the metabolic needs of the light-sensing photoreceptors in the retina. Illumination of the interior surface of the back of the eye (fundus) is a critical regulator of subretinal fluid homeostasis, which determines the overall shape of the eye, but it is also important for choroidal perfusion. Noted for having some of the highest blood flow rates in the body, the choroidal vasculature has been reported to lack intrinsic, intravascular pressure-induced (myogenic) autoregulatory mechanisms. Here, we ask how light directly regulates choroid perfusion and ocular fluid homeostasis, testing the hypothesis that light facilitates ocular fluid absorption by directly increasing choroid endothelial permeability and decreasing choroid perfusion. Utilizing ex vivo pressurized whole-choroid and whole-eye preparations from mice expressing cell-specific Ca

Indexed as

CalciumCalcium SignalingChoroidLightAnimalsEndothelial CellsHomeostasisMiceNitric OxideRetinaVasoconstrictionCalciumNitric OxideCa2+ signalingfluid homeostasisopsinsvasoconstriction

Identifiers

PMID39514305
PMCPMC11573543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.