Evidence map›Paper›PMID 39514242›Full record

ArticleClinical cardiology2024

Obesity Paradox and the Effect of NT-proBNP on All-Cause and Cause-Specific Mortality.

Rupinder Kaur Bahniwal, Nargiza Sadr, Colleen Schinderle, Cynthia J Avila, Julie Sill, Rehan Qayyum

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rupinder Kaur BahniwalDepartment of Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.ORCID http://orcid.org/0000-0001-7935-5725
Nargiza SadrDepartment of Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Colleen SchinderleDepartment of Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Cynthia J AvilaMassey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Julie SillDepartment of Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Rehan QayyumDepartment of Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.ORCID http://orcid.org/0000-0003-3086-8014

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

backgroundIn heart failure patients, obesity is associated with better outcomes as compared to normal weight, a phenomenon called the obesity paradox.

objectiveTo examine if obesity modifies the relationship between NT-proBNP and all-cause and cause-specific mortality in adults without coronary artery disease or heart failure history.

methodsWe used the National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2004 and linked it with mortality through December 31, 2019. Participants > 18 years were categorized into normal weight (BMI ≤ 25 kg/m

resultsOf the 12 621 participants, 2794 (22%) died during 202 859 person-years follow-up. In adjusted models, normal-weight participants with high NT-proBNP had 2 times higher all-cause mortality risk than those with low NT-proBNP (HR = 2.05; 95%CI = 1.74, 2.41; p < 0.001); however, this mortality risk was 27% lower in obese participants (HR interaction = 0.73; 95%CI = 0.59, 0.92; p = 0.008). Similarly, in normal-weight participants, the difference in other-cause mortality risk between high and low NT-proBNP participants was significant in adjusted models (HR = 2.27; 95%CI = 1.81, 2.85; p < 0.001) and obese participants had 48% lower other-cause mortality risk between those with high and low NT-proBNP (interaction HR = 0.52; 95%CI = 0.36, 0.77; p = 0.001). Conversely, obesity did not modify the relationship between NT-proBNP and cardiovascular or cancer mortality.

conclusionsIn patients free of heart failure or coronary artery disease, obesity may be protective against mortality associated with high NT-proBNP.

Indexed as

BiomarkersCause of DeathNatriuretic Peptide, BrainNutrition SurveysObesityPeptide FragmentsAdultAgedBody Mass IndexFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedObesity ParadoxBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)healthy populationmortalityNT‐proBNPobesity paradox

Identifiers

PMID39514242
PMCPMC11546245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.