Evidence map›Paper›PMID 39514171›Full record

ArticleMolecular neurobiology2025

Alzheimer's Disease-Derived Outer Membrane Vesicles Exacerbate Cognitive Dysfunction, Modulate the Gut Microbiome, and Increase Neuroinflammation and Amyloid-β Production.

Shouchao Wei, Xiaochen Ma, Yating Chen, Junjun Wang, Li Hu, Zhou Liu, Lang Mo, Ning Zhou, Wenrong Chen, He Zhu and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  10. EnterohemorrhagicFrontiers in cellular and infection microbiology · 2025
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shouchao WeiThe Third Department of Neurology, Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China.
Xiaochen MaThe Third Department of Neurology, Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China.
Yating ChenGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Junjun WangGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Li HuGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Zhou LiuGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Lang MoThe Third Department of Neurology, Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China.
Ning ZhouThe Third Department of Neurology, Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China.
Wenrong ChenThe Third Department of Neurology, Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China.
He ZhuZhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China. zhuhe1983@hust.edu.cn.
Shian YanThe Third Department of Neurology, Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China. shian_yan@126.com.

Funding

Doctoral Cooperation Project of Central People's Hospital of Zhanjiang 2021H03GuangDong Basic and Applied Basic Research Foundation 2021A151515010827Project of Traditional Chinese Medicine Bureau of Guangdong Province 20221444Zhanjiang City Science and Technology Development Special Fund Competitive Allocation Project 2021A05115
6 · The paper itself

Abstract

Although our understanding of the molecular biology of Alzheimer's disease (AD) continues to improve, the etiology of the disease, particularly the involvement of gut microbiota disturbances, remains a challenge. Outer membrane vesicles (OMVs) play a key role in central nervous system diseases, but the impact of OMVs on AD progression remains unclear. In this study, we hypothesized that AD-derived OMVs (OMVs

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCognitive DysfunctionGastrointestinal MicrobiomeNeuroinflammatory DiseasesAnimalsFatty Acids, VolatileHumansMaleMiceMice, Inbred C57BLMice, TransgenicAmyloid beta-PeptidesFatty Acids, VolatileAlzheimer’s diseaseGut microbiotaOuter membrane vesicles

Identifiers

PMID39514171

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.