Evidence map›Paper›PMID 39513963›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Genome-wide transcriptome analysis of Aβ deposition on PET in a Korean cohort.

Tamina Park, Jiyun Hwang, Shiwei Liu, Soumilee Chaudhuri, Sang Won Han, Dahyun Yi, Min Soo Byun, Yen-Ning Huang, Thea Rosewood, Gijung Jung and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Spotlight on Alzheimer's disease and related dementias research in East Asia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  2. Genome-wide transcriptome analysis of Aβ deposition on PET in a Korean cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Tamina ParkCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jiyun HwangGenome and Health Big Data Laboratory Graduate School of Public Health, , Seoul National University, Seoul, South Korea.
Shiwei LiuCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Soumilee ChaudhuriCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sang Won HanDepartment of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon-si, South Korea.
Dahyun YiInstitute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, South Korea.
Min Soo ByunDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
Yen-Ning HuangCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Thea RosewoodCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Gijung JungDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
Min Jeong KimDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
Hyejin AhnDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
Jun-Young LeeDepartment of Psychiatry, Seoul National University Boramae Medical Center, Seoul, South Korea.
Yu Kyeong KimDepartment of Psychiatry, Seoul National University Boramae Medical Center, Seoul, South Korea.
MinYoung ChoCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Paula J BiceCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hannah CraftCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Shannon L RisacherCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hongyu GaoDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Yunlong LiuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
SangYun KimDepartment of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam-si, South Korea.
Young Ho ParkDepartment of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam-si, South Korea.
Dong Young LeeInstitute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, South Korea.
Andrew J SaykinCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kwangsik NhoCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Leslie Michael Shaw · 2016 to 2026
$226.7M
Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Minerva Maria Carrasquillo, NILUFER ERTEKIN-TANER · 2023 to 2026
$42.0M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
KBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems BiologyU01AG072177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LEE, DONG YOUNG, NHO, KWANGSIK TIMOTHY · 2021 to 2025
$11.2M
Memory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9M
Leveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's DiseaseR01AG057739 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI APOSTOLOVA, LIANA G, PERRY, BREA LOUISE · 2018 to 2022
$3.5M
Cognitive Aging, Alzheimers disease, and Cancer-related Cognitive DeclineR01AG068193 · NIA · GEORGETOWN UNIVERSITY · PI MANDELBLATT, JEANNE, SAYKIN, ANDREW J · 2020 to 2023
$2.8M
Training Grant on Alzheimer's Disease and ADRD at Indiana UniversityT32AG071444 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GARY E. LANDRETH, Bruce T Lamb · 2021 to 2026
$2.8M
Integrating Neuroimaging, Multi-omics, and Clinical Data in Complex DiseaseR01LM012535 · NLM · INDIANA UNIVERSITY INDIANAPOLIS · PI NHO, KWANGSIK TIMOTHY · 2017 to 2021
$1.7M
Informatics Algorithms for Genomic Analysis of Brain Imaging DataR01LM013463 · NLM · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H., SAYKIN, ANDREW J · 2020 to 2023
$1.4M
Foundation for the National Institutes of Health R01AG068193Foundation for the National Institutes of Health R01LM012535Foundation for the National Institutes of Health R01LM013463Foundation for the National Institutes of Health T32AG071444Foundation for the National Institutes of Health U01AG068057Foundation for the National Institutes of Health U01AG072177Foundation for the National Institutes of Health U19AG074879Korean government grants HI18C0630Korean government grants HI19C0149Korean government grants NRF-2014M3C7A1046042Korean government grants RS-2022-00165636Korean government grants RS-2023-KH136195Ministry of Science and ICT, South Korea 2020R1C1C1013718NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG057739NIA NIH HHS R01 AG068193NIA NIH HHS T32 AG071444NIA NIH HHS U01 AG068057NIA NIH HHS U01 AG072177NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG074879NLM NIH HHS R01 LM012535NLM NIH HHS R01 LM013463
6 · The paper itself

Abstract

introductionDespite the recognized importance of including ethnic diversity in Alzheimer's disease (AD) research, substantial knowledge gaps remain, particularly in Asian populations.

methodsRNA sequencing was performed on blood samples from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) to perform differential gene expression (DGE), gene co-expression network, gene-set enrichment, and machine learning analyses for amyloid beta (Aβ) deposition on positron emission tomography.

resultsDGE analysis identified 265 dysregulated genes associated with Aβ deposition and replicated three AD-associated genes in an independent Korean cohort. Network analysis identified two modules related to pathways including a natural killer (NK) cell-mediated immunity. Machine learning analysis showed the classification of Aβ positivity improved with the inclusion of gene expression data. DISCUSSION: Our results in a Korean population suggest Aβ deposition-associated genes are enriched in NK cell-mediated immunity, providing a better understanding of AD molecular mechanisms and yielding potential diagnostic and therapeutic strategies. HIGHLIGHTS: Dysregulated genes were associated with amyloid beta (Aβ) deposition on positron emission tomography in a Korean cohort. Dysregulated genes in Alzheimer's disease were replicated in an independent Korean cohort. Gene network modules were associated with Aβ deposition. Natural killer (NK) cell proportion in blood was associated with Aβ deposition. Dysregulated genes were related to a NK cell-mediated immunity.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesPositron-Emission TomographyAgedBrainCohort StudiesFemaleGene Expression ProfilingGenome-Wide Association StudyHumansKiller Cells, NaturalMachine LearningMaleRepublic of KoreaTranscriptomeAmyloid beta-PeptidesAlzheimer's diseaseamyloid betaAsian populationdiagnosisKorean cohortneuroimagingtranscriptomics

Identifiers

PMID39513963
PMCPMC11667488

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.