Evidence map›Paper›PMID 39513920›Full record

ArticleCells2024

The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells.

Snezhanna Kandrashina, Ekaterina Sherstyukova, Mikhail Shvedov, Vladimir Inozemtsev, Roman Timoshenko, Alexander Erofeev, Maxim Dokukin, Viktoria Sergunova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Snezhanna KandrashinaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.ORCID 0000-0002-2185-3817
Ekaterina SherstyukovaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.ORCID 0000-0002-9962-6315
Mikhail ShvedovFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.ORCID 0009-0004-4288-2758
Vladimir InozemtsevFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.ORCID 0000-0002-4693-5624
Roman TimoshenkoResearch laboratory of biophysics, National University of Science and Technology "MISIS", 119049 Moscow, Russia.
Alexander ErofeevResearch laboratory of biophysics, National University of Science and Technology "MISIS", 119049 Moscow, Russia.
Maxim DokukinSarov Physics and Technology Institute, MEPhI, 607186 Sarov, Russia.ORCID 0000-0001-6856-1953
Viktoria SergunovaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.ORCID 0000-0002-8425-0845

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Red blood cells respond to fluctuations in blood plasma pH by changing the rate of biochemical and physical processes that affect the specific functions of individual cells. This study aimed to analyze the effect of pH changes on red blood cell morphology and structure. The findings revealed that an increase or decrease in pH above or below the physiological level of pH 7.4 results in the transformation of discocytes into echinocytes and causes significant alterations in the membrane, including its roughness, cytoskeleton structure, and the cell's elastic modulus. Furthermore, the study shown a strong connection between critical acidosis and alkalosis with increased intracellular reactive oxygen species production.

Indexed as

Acid-Base ImbalanceCell ShapeErythrocytesReactive Oxygen SpeciesCytoskeletonElastic ModulusHumansHydrogen-Ion ConcentrationReactive Oxygen SpeciesAFMcytoskeletonelastic modulusnanostructurepHred blood cellROSSICM

Identifiers

PMID39513920
PMCPMC11545479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.