Evidence map›Paper›PMID 39513894›Full record

ArticleCells2024

Adipose Tissue Macrophages of the Human Fetus.

Ádám Radványi, Katalin Gyurina, Emese Rácz, Ilona Kovács, Gábor Méhes, Tamás Röszer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ádám RadványiDepartment of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-5907-2725
Katalin GyurinaDepartment of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Emese RáczDepartment of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Ilona KovácsDepartment of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Gábor MéhesDepartment of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Tamás RöszerDepartment of Pediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0003-1903-7922

Funding

Hungarian Academy of Sciences BolyaiHungarian Research Fund NKFI-142939
6 · The paper itself

Abstract

Prenatal adipose tissue development affects body composition and growth trajectory in early infancy, therefore it is a key determinant of adiposity in childhood. Childhood overweight and obesity increase the probability of being obese as an adult. After birth and in adulthood, adipose tissue macrophages (ATMs) are relevant constituents of the fat depots, and they are necessary for physiological adipose tissue development and fat metabolism. In obesity, however, ATMs may induce chronic inflammation leading to insulin resistance, pancreatic beta cell damage and self-immunity. Despite being relevant regulators of adipose tissue development and functioning, it is unknown whether ATMs are present in the fetal adipose tissue, therefore it is elusive whether they may affect the prenatal establishment of fat depots. Here we studied the distribution of ATMs in the human fetus between gestational weeks 17 and 38 and labeled ATMs in the early postnatal life. We found that CD45

Indexed as

Adipose TissueFetusMacrophagesAntigens, CDFemaleHumansInfant, NewbornInterleukin-6PregnancyAntigens, CDInterleukin-6adipose tissuehuman developmentimmunitymacrophagesmetabolism

Identifiers

PMID39513894
PMCPMC11545370

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.