Evidence map›Paper›PMID 39513877›Full record

ArticleCells2024

Acute Chikungunya Infection Induces Vascular Dysfunction by Directly Disrupting Redox Signaling in Endothelial Cells.

José Teles de Oliveira-Neto, Juliano de P Souza, Daniel Rodrigues, Mirele R Machado, Juliano V Alves, Paula R Barros, Alecsander F Bressan, Josiane F Silva, Tiago J Costa, Rafael M Costa and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

José Teles de Oliveira-NetoDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.ORCID 0000-0001-9143-0193
Juliano de P SouzaDepartment of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.
Daniel RodriguesDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.ORCID 0000-0002-5967-1576
Mirele R MachadoDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.
Juliano V AlvesDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.
Paula R BarrosDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.ORCID 0000-0001-5428-8490
Alecsander F BressanDepartment of Basic Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá 79070-900, Brazil.ORCID 0000-0001-7629-8972
Josiane F SilvaDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.ORCID 0000-0002-6623-7946
Tiago J CostaInstitute of Biomedical Sciences, University of Sao Paulo, Ribeirão Preto 05508-000, Brazil.ORCID 0000-0003-0780-4290
Rafael M CostaDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.ORCID 0000-0002-5174-5710
Daniella BonaventuraInstitute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-5253-4918
Eurico de Arruda-NetoDepartment of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.
Rita C TostesDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.ORCID 0000-0002-9446-0707
Emiliana P AbrãoDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto 14040-900, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/08216-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/ 08176-1National Council for Scientific and Technological Development 133912/2019-1
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) infection is characterized by febrile illness, severe joint pain, myalgia, and cardiovascular complications. Given that CHIKV stimulates reactive oxygen species (ROS) and pro- and anti-inflammatory cytokines, events that disrupt vascular homeostasis, we hypothesized that CHIKV induces arterial dysfunction by directly impacting redox-related mechanisms in vascular cells. Wild-type (WT) and iNOS

Indexed as

Chikungunya FeverChikungunya virusEndothelial CellsOxidation-ReductionSignal TransductionAnimalsCytokinesHumansMaleMiceMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type IIReactive Oxygen SpeciesCytokinesNitric Oxide Synthase Type IIReactive Oxygen SpeciesChikungunyanitric oxide synthasereactive oxygen speciesvascular dysfunction

Identifiers

PMID39513877
PMCPMC11544861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.