Evidence map›Paper›PMID 39513591›Full record

ArticleInternational journal of molecular medicine2025

Enocyanin promotes osteogenesis and bone regeneration by inhibiting MMP9.

Wei Mao, Yinfeng Zheng, Wencong Zhang, Jinrong Yin, Zhiyi Liu, Peiliang He, Guodong Hou, Guowei Huang, Huan Chen, Junyan Lin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei Mao *Guangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Yinfeng Zheng *Guangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Wencong Zhang *Guangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Jinrong YinGuangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Zhiyi LiuGuangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Peiliang HeGuangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Guodong HouGuangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Guowei HuangGuangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Huan ChenGuangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Junyan LinGuangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Jiake XuSchool of Biomedical Science, The University of Western Australia, Perth 6009, Australia.
Aiguo LiGuangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Shengnan QinGuangzhou Institute of Traumatic Surgery, Department of Orthopaedics, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enocyanin (ENO), an anthocyanin extracted from grapes, has been shown to exert inhibitory effects on acid phosphatase and inflammation; however, its role in osteogenesis and bone formation is currently unknown. The present study aimed to investigate the effects of ENO on osteogenesis

Indexed as

Bone RegenerationMatrix Metalloproteinase 9OsteogenesisAnimalsCell DifferentiationCell LineMaleMiceWnt Signaling PathwayMatrix Metalloproteinase 9bone regenerationenocyaninfemur fracturematrix metalloproteinase 9osteogenesis

Identifiers

PMID39513591
PMCPMC11554379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.