ArticleUnited European gastroenterology journal2024
Sex-related differences in the presentation, management and response to treatment of eosinophilic esophagitis: Cross sectional analysis of EoE CONNECT registry.
Article in United European gastroenterology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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7citing papers in PubMed, 1 pooled it
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1 · What the graph read from it
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2 · The registry
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3 · Its place in the literature
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7 citing papers in PubMed, 1 synthesis or guideline pooled it.
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5 · Who and what money
Authors and funding
51 authors.
Emilio J Laserna-MendietaDepartment of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.ORCID 0000-0002-9039-7667
Sergio Casabona-FrancésInstituto de Investigación Sanitaria La Princesa, Madrid, Spain.ORCID 0000-0002-6131-8341
Edurne AmorenaDepartment of Gastroenterology, Complejo Universitario de Navarra, Pamplona, Spain.ORCID 0000-0002-2539-0514
Edoardo V SavarinoSurgery, Oncology and Gastroenterology, Gastroenterology Unit, Azienza Ospedaliera di Padova, Padova, Italy.ORCID 0000-0002-3187-2894
Isabel Pérez-MartínezDepartment of Gastroenterology, Hospital Universitario Central de Asturias, Oviedo, Spain.ORCID 0000-0002-2535-1929
Leonardo Blas-JhonDepartment of Gastroenterology, Fundación Jiménez Díaz, Madrid, Spain.ORCID 0000-0001-9673-345X
Antonio Guardiola-ArévaloDepartment of Gastroenterology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain.ORCID 0000-0002-4584-4616
Marina ColettaDepartment of Gastroenterology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-2196-8761
Gaia PellegattaEndoscopy Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy.ORCID 0000-0003-0235-4905
Danila GuagnozziCentro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas, Madrid, Spain.ORCID 0000-0002-6171-1901
Jesús BarrioDepartment of Gastroenterology, Hospital Universitario Rio Hortega, Valladolid, Spain.ORCID 0000-0001-7087-3921
Antonia PerelloDepartment of Gastroenterology, Hospital Universitari Son Espases, Palma de Mallorca, Spain.ORCID 0000-0003-4137-8790
Elena BetoréDepartment of Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain.ORCID 0000-0002-4636-0453
Anne Lund KrarupDepartment of Emergency Medicine and Trauma Center, Department of Gastroenterology and Hepatology, Aalborg University Hospital and Institute of Clinical Medicine Aalborg University, Aalborg, Denmark.ORCID 0000-0002-2228-7132
Martina VottoPediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.ORCID 0000-0002-4271-8649
Carolina Gutiérrez-JunqueraDepartment of Pediatric Gastroenterology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.ORCID 0000-0003-0313-7072
Juan Enrique NavesDepartment of Gastroenterology, Hospital del Mar, Barcelona, Spain.ORCID 0000-0002-0202-1302
Salvatore OlivaDepartment of Pediatric Digestive Endoscopy, University Hospital Umberto I & Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-2348-2308
Carlos Teruel Sánchez-VegazoDepartment of Gastroenterology, Hospital Universitario Ramón y Cajal, Madrid, Spain.ORCID 0000-0001-6626-2933
Silvia CarriónCentro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas, Madrid, Spain.ORCID 0000-0002-1354-2488
Susana de la RivaDepartment of Gastroenterology, Clínica Universidad de Navarra, Pamplona, Spain.ORCID 0000-0002-5511-5644
Silvia Espina-CadenasDepartment of Gastroenterology, Hospital General de la Defensa, Zaragoza, Spain.ORCID 0000-0003-1632-9903
Mónica Llorente-BarrioDepartment of Gastroenterology, Hospital de Santa Bárbara, Soria, Spain.ORCID 0000-0003-0267-989X
Irene Pascual-LopezDepartment of Gastroenterology, Hospital Universitario Arnau de Vilanova & Hospital Universitario Santa María, Lérida, Spain.ORCID 0009-0005-1914-1713
María Luisa Masiques-MasDepartment of Pediatric Gastroenterology, Hospital de Granollers, Granollers, Spain.ORCID 0000-0001-6496-1239
Raúl Honrubia-LópezDepartment of Gastroenterology, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Spain.ORCID 0000-0003-0029-9885
Raffaella DaineseDepartment of Gastroenterology, Centre Hospitalier d'Antibes Juan-les-Pins, Antibes, France.ORCID 0000-0002-8829-6410
Natalia García-MoralesDepartment of Gastroenterology, Hospital Álvaro Cunquerio, Vigo, Spain.ORCID 0000-0003-0130-3778
Julyssa CobianDepartment of Gastroenterology, Hospital Donostia, San Sebastián, Spain.ORCID 0000-0002-7579-439X
Juan Khaled Bisso-ZeinDepartment of Gastroenterology, Hospital Costa del Sol, Marbella, Spain.
Valentín RoalesDepartment of Gastroenterology, Hospital Clínico Universitario San Carlos, Madrid, Spain.ORCID 0000-0003-4322-8956
Alba Juan-JuanDepartment of Gastroenterology, Hospital Sant Joan Despí Moisès Broggi, Barcelona, Spain.ORCID 0000-0002-6634-6675
Alba Rodríguez-SánchezDepartment of Gastroenterology, Hospital Universitario Santa Lucía, Cartagena, Spain.
Sara Feo-OrtegaInstituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Madrid, Spain.ORCID 0000-0002-0018-4730
Verónica Martín-DomínguezInstituto de Investigación Sanitaria La Princesa, Madrid, Spain.ORCID 0000-0001-6839-2707
Óscar Nantes-CastillejoDepartment of Gastroenterology, Complejo Universitario de Navarra, Pamplona, Spain.ORCID 0000-0002-3587-1039
Julia Nicolay-ManeruDepartment of Gastroenterology, Complejo Universitario de Navarra, Pamplona, Spain.
Matteo GhisaSurgery, Oncology and Gastroenterology, Gastroenterology Unit, Azienza Ospedaliera di Padova, Padova, Italy.ORCID 0000-0002-6026-5639
Daria ManieroSurgery, Oncology and Gastroenterology, Gastroenterology Unit, Azienza Ospedaliera di Padova, Padova, Italy.ORCID 0000-0003-2468-7292
Adolfo SuarezDepartment of Gastroenterology, Hospital Universitario Central de Asturias, Oviedo, Spain.ORCID 0000-0001-7149-6814
Iván MarayDiet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.ORCID 0000-0002-8204-5178
Marta Álvarez-GarcíaDepartment of Gastroenterology, Fundación Jiménez Díaz, Madrid, Spain.ORCID 0000-0003-4818-9968
Alicia Granja-NavacerradaDepartment of Gastroenterology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain.ORCID 0000-0001-6956-4240
Roberto PenaginiDepartment of Gastroenterology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0001-6918-9479
Francesca RaccaPersonalized Medicine, Asthma and Allergy Clinic, IRCCS Humanitas Research Hospital, Rozzano - Milan, Italy.ORCID 0000-0001-9560-9238
Ronald Llerena-CastroDepartment of Gastroenterology, Hospital Universitario Vall d'Hebrón, Barcelona, Spain.ORCID 0000-0001-6860-1724
Cecilio SantanderInstituto de Investigación Sanitaria La Princesa, Madrid, Spain.ORCID 0000-0001-5492-2535
Ángel AriasInstituto de Investigación Sanitaria La Princesa, Madrid, Spain.ORCID 0000-0003-1006-0958
Alfredo J LucendoDepartment of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.ORCID 0000-0003-1183-1072
EUREOS and EoE CONNECT research group
Funding
EUREOS
6 · The paper itself
Abstract
backgroundEosinophilic esophagitis (EoE) predominantly affects males across all ages; however, little is known about sex differences for other aspects of EoE.
objectiveTo investigate associations between sex and clinical presentation, endoscopic features, treatment choice and response in EoE patients in real-world practice.
methodsCross-sectional analysis of the multicenter EoE CONNECT registry. The independent contribution of patients' sex and other relevant variables were statistically assessed by multivariate models.
resultsA total of 2976 patients (76% male) were evaluated. Males were diagnosed at a younger age compared to females (32.7 ± 14.8 vs. 34.8 ± 15.6 years, respectively; p = 0.002) with similar diagnostic delay. EoE symptoms varied significantly between sexes, with food impaction predominating in males and dysphagia, heartburn, regurgitation and abdominal and epigastric pain in females. However, female sex contributed to higher symptom severity at diagnosis as measured with Dysphagia Symptom Score (R
conclusionsSex is associated with clinical and phenotypical presentation of EoE at diagnosis, with more fibrotic findings in males but higher symptom score in females.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Sex-related differences in the presentation, management and response to treatment of eosinophilic esophagitis: Cross sectional analysis of EoE CONNECT registry. · full record | OpenQuestion