Evidence map›Paper›PMID 39513400›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2024

Transition to Enteral Triazole Antifungal Therapy for Pediatric Invasive Candidiasis: Secondary Analysis of a Multicenter Cohort Study Conducted by the Pediatric Fungal Network.

Robert F T Bucayu, Craig L K Boge, Inci Yildirim, Martha Avilés-Robles, Surabhi B Vora, David M Berman, Tanvi S Sharma, Lillian Sung, Elio Castagnola, Debra L Palazzi and 31 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Brazilian guidelines for the diagnosis and treatment of candidemia and invasive candidiasis in adults and children.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Guideline
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Robert F T BucayuDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Craig L K BogeDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Inci YildirimDepartment of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
Martha Avilés-RoblesDepartment of Infectious Diseases, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
Surabhi B VoraDepartment of Pediatrics, University of Washington and Division of Infectious Diseases, Seattle Children's Hospital, Seattle, Washington, USA.ORCID 0000-0002-9344-5185
David M BermanMedical Affairs, Karius, Inc., Redwood City, California, USA.
Tanvi S SharmaDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0009-0005-3452-0666
Lillian SungDivision of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0003-0951-3091
Elio CastagnolaDepartment of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Debra L PalazziDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
Lara Danziger-IsakovDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-5691-5221
Dwight E YinDepartment of Pediatrics, Children's Mercy Kansas City, University of Missouri-Kansas City, Missouri, USA.ORCID 0000-0002-8599-1004
Emmanuel RoilidesInfectious Diseases Unit, 3rd Department of Pediatrics, Aristotle University and Hippokration Hospital, Thessaloniki, Greece.ORCID 0000-0002-0202-364X
Gabriela MaronDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0001-5247-5399
Alison C TribbleDepartment of Pediatrics, Division of Pediatric Infectious Diseases, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan, USA.
Pere Soler-PalacinDepartment of Paediatrics, Paediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain.ORCID 0000-0002-0346-5570
Eduardo López-MedinaCentro de Estudios en Infectología Pediátrica, Clínica Imbanaco Grupo Quirónsalud and Universidad del Valle, Cali, Colombia.ORCID 0000-0003-3066-5938
José RomeroNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Kiran BelaniPediatric Infectious Diseases, Children's Minnesota, Minneapolis, Minnesota, USA.
Antonio C ArrietaDepartment of Infectious Diseases, Children's Hospital of Orange County, Orange, California, USA.
Fabianne CarlesseInstituto de Oncologia Pediatrica-IOP/GRAACC-UNIFESP, São Paulo, Brazil.
Dawn NoltDivision of Pediatric Infectious Diseases, Oregon Health & Science University and Doernbecher Children's Hospital, Portland, Oregon, USA.
Natasha HalasaDepartment of Pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.
Daniel DulekDepartment of Pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.
Sujatha RajanDivision of Pediatric Infectious Diseases, Northwell, Cohen Children's Medical Center, New Hyde Park, New York, USA.
William J MullerDepartment of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Monica I ArduraDivision of Infectious Diseases and Host Defense Program, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-2853-2581
Alice PongDepartment of Pediatrics, University of California San Diego and Rady Children's Hospital San Diego, San Diego, California, USA.
Blanca E GonzalezCenter for Pediatric Infectious Diseases, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Christine M SalvatoreDivision of Pediatric Infectious Diseases, Weill Cornell Medicine and Komansky Children's Hospital, New York, New York, USA.ORCID 0000-0002-2087-1044
Anna R HupplerDepartment of Pediatrics, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, Wisconsin, USA.
Catherine AftandilianDivision of Pediatric Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Stanford University School of Medicine, Palo Alto, California, USA.
Mark J AbzugDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, USA.
Arunaloke ChakrabartiDoodhadhar Burfani Hospital and Research Institute, Haridwar, India.ORCID 0000-0003-1555-3807
Michael GreenDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pennsylvania, USA.
Irja LutsarDepartment of Microbiology, University of Tartu, Tartu, Estonia.
Elizabeth D KnackstedtDivision of Pediatric Infectious Diseases, University of Utah, Salt Lake City, Utah, USA.
Sarah K JohnsonDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
William J SteinbachDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Brian T FisherDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-8224-4281
Rachel L WattierDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-5271-4705

Funding

UCSF-Kaiser Urological Epidemiology Research Career Development ProgramK12DK111028 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ALISON · 2016 to 2025
$5.3M
Multi-center studies to improve diagnosis and treatment of pediatric candidiasisR01AI103315 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI STEINBACH, WILLIAM J, ZAOUTIS, THEOKLIS · 2013 to 2017
$2.9M
NIAID NIH HHS R01 AI103315NIDDK NIH HHS K12 DK111028
6 · The paper itself

Abstract

Of 319 children with invasive candidiasis, 67 (21%) transitioned from intravenous to enteral antifungal therapy. Eight (12%) transitioned back to intravenous antifungal therapy, one due to perceived treatment failure defined by clinical progression or worsening. Global treatment response at study completion was successful in 66 participants who transitioned to enteral therapy.

Indexed as

Antifungal AgentsCandidiasis, InvasiveAdministration, IntravenousAdolescentChildChild, PreschoolCohort StudiesFemaleHumansInfantMaleTreatment OutcomeTriazolesAntifungal AgentsTriazolesantifungal agentcandidemiafluconazoleinvasive candidiasisoral drug administration

Identifiers

PMID39513400
PMCPMC12476979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.