Evidence map›Paper›PMID 39513312›Full record

ArticleCurrent neuropharmacology2025

Early Enteral Feeding Restores Neurofilament Light Chain Serum Levels in Preterm Newborns.

Maria Di Chiara, Gianluca Terrin, Marco Fiore, Maria Chiara De Nardo, Gianluigi Laccetta, Flavia Gloria, Antonio Minni, Christian Barbato, Carla Petrella

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Article in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Maria Di ChiaraDepartment of Mother and Child Health, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Gianluca TerrinDepartment of Mother and Child Health, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Marco FioreInstitute of Biochemistry and Cell Biology (IBBC) of the National Research Council (CNR), Rome, Italy.
Maria Chiara De NardoDepartment of Mother and Child Health, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Gianluigi LaccettaDepartment of Mother and Child Health, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Flavia GloriaDepartment of Mother and Child Health, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Antonio MinniDepartment of Sense Organs DOS, Sapienza University of Rome, Rome, Italy.
Christian BarbatoInstitute of Biochemistry and Cell Biology (IBBC) of the National Research Council (CNR), Rome, Italy.
Carla PetrellaInstitute of Biochemistry and Cell Biology (IBBC) of the National Research Council (CNR), Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPositive effects of early nutritional strategies on neurological outcomes have been observed when nutrients were administered by the enteral route, especially during the first week of life. Evidence reports that serum neurofilament light chain (NfL), a structural protein of neurons, is a specific and reliable biomarker of neuronal damage.

objectiveThe present study aimed to investigate the effect of early enteral nutrition (EN) in minimizing neuroaxonal damage and assessing NfL serum levels in preterm neonates.

methodsFifty-four preterm neonates without severe brain impairment and 20 full-term babies as controls were enrolled from the Neonatal Intensive Care Unit at the Policlinico Umberto I in Rome. We performed blood sampling at birth (day of life 0 - DoL 0) in 20 full-term newborns and in 19 pre-term infants. Furthermore, we executed blood sampling at DoL 28 in other 22 pre-term newborns who received early enteral nutrition (EN) within the third DoL (Early-EN) and in 13 other pre-term newborns who received EN after the third DoL (Late-EN).

resultsSerum levels of NfL were higher in preterm babies when compared to full-term neonates, at DoL 0 (48.81 ± 9.4 vs. 11.67 ± 1.4 pg/ml; p = 0.007). Interestingly, at DoL 28, serum NfL was significantly decreased in the Early-EN newborns compared to the Late-EN groups (15.22 ± 2.0 vs. 50.05 ± 17.9 pg/ml; p = 0.03).

conclusionIt was shown that early enteral feeding, within the first week of life, could be a useful tool for limiting neurological impairment in pre-term neonates by restoring NfL.

Indexed as

Enteral NutritionInfant, PrematureNeurofilament ProteinsBiomarkersFemaleHumansInfant, NewbornMaleBiomarkersneurofilament protein LNeurofilament Proteinsbiomarker.early enteral feedingneurodevelopmentneurofilament light chainnutritionPre-terms

Identifiers

PMID39513312
PMCPMC11808586

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