Evidence map›Paper›PMID 39513219›Full record

ReviewFuture cardiology2024

miRNAs in the diagnosis and therapy of cardiac and mediastinal tumors: a new dawn for cardio-oncology?

Francesco Loreni, Antonio Nenna, Francesco Nappi, Chiara Ferrisi, Camilla Chello, Mario Lusini, Bruno Vincenzi, Giuseppe Tonini, Massimo Chello

Abstract readReview
In one paragraph

Review in Future cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesco LoreniCardiac Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy.
Antonio NennaCardiac Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy.ORCID 0000-0002-4069-6781
Francesco NappiCardiac Surgery, Centre Cardiologique du Nord, Saint Denis, 93200, France.
Chiara FerrisiCardiac Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy.
Camilla ChelloPhD Course of Integrated Biomedical Sciences, Università Campus Bio-Medico di Roma, Rome, 00128, Italy.
Mario LusiniCardiac Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy.
Bruno VincenziOncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy.
Giuseppe ToniniOncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy.
Massimo ChelloCardiac Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunctions in miRNA production have been recently investigated as predictors of neoplasms and their therapeutic strategies. In this review, we summarize the available knowledge on miRNAs and cardiac tumors (such as myxoma) and mediastinal tumors (such as thymoma) and propose new avenues for future research. MiRNAs are crucial for cardiac development through the expression of cardiac transcription factors (miR-335-5p), hinder the cell cycle by modulating the activity of transcription factors (miR-126-3p, miR-320a), modulate the production of inflammatory factors such as interleukins (miR-217), and interfere with cell proliferation or apoptosis (miR-218, miR-634 and miR-122). Current and future research on miRNAs is essential, as a deep understanding could lead to a revolution in the field of diagnostics and prevention of neoplastic diseases.

Indexed as

Heart NeoplasmsMediastinal NeoplasmsMicroRNAsBiomarkers, TumorCardio-OncologyHumansBiomarkers, TumorMicroRNAscardiac surgerycardiac tumorsdiagnosisheart teammesotheliomamiRNAmyxomapreventionthoracic surgery

Identifiers

PMID39513219
PMCPMC11622773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.