Evidence map›Paper›PMID 39513195›Full record

ArticleEuropean journal of immunology2025

Characterization of the Molecular Signature of Human Monocytes in Aging and Myelodysplastic Neoplasms.

Christina Maria Rimpa, Maria Grigoriou, Athanasios Tasis, Nikolaos Paschalidis, Anastasia Filia, Giannis Vatsellas, Panagiotis Papazoglou, Antonios Chatzigeorgiou, Chrysa Kymparidou, Menelaos Papoutselis and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Christina Maria RimpaDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.ORCID 0000-0002-7771-7419
Maria GrigoriouDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Athanasios TasisDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Nikolaos PaschalidisBiomedical Research Foundation of the Academy of Athens, Athens, Greece.
Anastasia FiliaDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Giannis VatsellasBiomedical Research Foundation of the Academy of Athens, Athens, Greece.
Panagiotis PapazoglouDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Antonios ChatzigeorgiouMedical School, National and Kapodistrian University of Athens, Athens, Greece.
Chrysa KymparidouDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Menelaos PapoutselisDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Christina MisidouDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Theodoros SpyropoulosDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Despoina DimitriouDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Haralampos HatzikirouMathematics Department, Khalifa University, Abu Dhabi, UAE.
Konstantinos LiapisDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Eleftheria LamprianidouDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Ioannis KotsianidisDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Ioannis MitroulisDepartment of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.

Funding

Hellenic Foundation for Research and Innovation HFRI-FM17-452Khalifa University RIG-2023-051
6 · The paper itself

Abstract

• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. • Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations. • MDS shows reduced inflammatory activity in CD14

Indexed as

AgingMonocytesMyelodysplastic SyndromesAgedFemaleHumansInflammationMaleMiddle Agedagingchronic inflammationinflammagingmonocytesmyelodysplastic neoplasm (MDS)

Identifiers

PMID39513195
PMCPMC11739662

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.