Evidence map›Paper›PMID 39513142›Full record

ReviewCardiovascular diagnosis and therapy2024

Pulmonary hypertension in adults with congenital heart defects (ACHDs) in light of the 2022 ESC PAH guidelines-part II: supportive therapy, special situations (pregnancy, contraception, non-cardiac surgery), targeted pharmacotherapy, organ transplantation, special management (shunt lesion, left ventricular disease, univentricular hearts), interventions, intensive care, ACHD follow-up, future perspective.

Harald Kaemmerer, Gerhard Paul Diller, Ingo Dähnert, Stephan Achenbach, Christina A Eichstaedt, Andreas Eicken, Annika Freiberger, Sebastian Freilinger, Ralf Geiger, Matthias Gorenflo and 14 more

Abstract readReview
In one paragraph

Review in Cardiovascular diagnosis and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. ESC guidelines 2025 on cardiovascular disease and pregnancy: considerations and future perspectives.European heart journal supplements : journal of the European Society of Cardiology · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Harald KaemmererInternational Center for Adults with Congenital Heart Defects, Clinic for Congenital Heart Defects and Pediatric Cardiology, Deutsches Herzzentrum München, TUM University Hospital, Munich, Germany.
Gerhard Paul DillerDepartment of Cardiology III: Congenital Heart Malformations (ACHD) and Valve Diseases, University Hospital Münster, Münster, Germany.
Ingo DähnertUniversity Clinic for Pediatric Cardiology, Heart Center Leipzig, Leipzig, Germany.
Stephan AchenbachUniversity Hospital Erlangen, Medizinische Klinik 2 - Kardiologie und Angiologie, Erlangen, Germany.
Christina A EichstaedtCenter for Pulmonary Hypertension, Thorax Clinic Heidelberg at Heidelberg University Hospital, Heidelberg, Germany.
Andreas EickenInternational Center for Adults with Congenital Heart Defects, Clinic for Congenital Heart Defects and Pediatric Cardiology, Deutsches Herzzentrum München, TUM University Hospital, Munich, Germany.
Annika FreibergerInternational Center for Adults with Congenital Heart Defects, Clinic for Congenital Heart Defects and Pediatric Cardiology, Deutsches Herzzentrum München, TUM University Hospital, Munich, Germany.
Sebastian FreilingerInternational Center for Adults with Congenital Heart Defects, Clinic for Congenital Heart Defects and Pediatric Cardiology, Deutsches Herzzentrum München, TUM University Hospital, Munich, Germany.
Ralf GeigerDepartment of Pediatrics III, Cardiology, Pneumology, Allergology, Cystic Fibrosis, Innsbruck, Austria.
Matthias GorenfloDepartment of Pediatric Cardiology and Congenital Heart Defects, Heidelberg University Hospital, Heidelberg, Germany.
Ekkehard GrünigCenter for Pulmonary Hypertension, Thorax Clinic Heidelberg at Heidelberg University Hospital, Heidelberg, Germany.
Alfred HagerInternational Center for Adults with Congenital Heart Defects, Clinic for Congenital Heart Defects and Pediatric Cardiology, Deutsches Herzzentrum München, TUM University Hospital, Munich, Germany.
Michael HuntgeburthInternational Center for Adults with Congenital Heart Defects, Clinic for Congenital Heart Defects and Pediatric Cardiology, Deutsches Herzzentrum München, TUM University Hospital, Munich, Germany.
Ann-Sophie Kaemmerer-SuleimanDepartment of Cardiac Surgery, Erlangen University Hospital, Erlangen, Germany.
Rainer Kozlik-FeldmannClinic and Polyclinic for Pediatric Cardiology, Hamburg University Heart and Vascular Center, Clinic and Polyclinic for Pediatric Heart Medicine and Adults with Congenital Heart Defects, Hamburg, Germany.
Astrid E LammersDepartment of Pediatric Cardiology, University Hospital Münster, Münster, Germany.
Nicole NagdymanInternational Center for Adults with Congenital Heart Defects, Clinic for Congenital Heart Defects and Pediatric Cardiology, Deutsches Herzzentrum München, TUM University Hospital, Munich, Germany.
Sebastian MichelDivision for Congenital and Pediatric Heart Surgery, Department of Cardiac Surgery, Ludwig Maximilian University Munich, Campus Großhadern, Munich, Germany.
Kai Helge SchmidtUniversity Medical Center Mainz, Center for Cardiology - Cardiology I, Johannes Gutenberg University Mainz, Mainz, Germany.
Mathieu SuleimanDepartment of Cardiac Surgery, Erlangen University Hospital, Erlangen, Germany.
Anselm UebingUniversity Hospital Schleswig-Holstein, Clinic for Congenital Heart Defects and Pediatric Cardiology, Kiel, Germany.
Fabian von ScheidtInternational Center for Adults with Congenital Heart Defects, Clinic for Congenital Heart Defects and Pediatric Cardiology, Deutsches Herzzentrum München, TUM University Hospital, Munich, Germany.
Ulrike HerbergDepartment of Pediatric Cardiology (U.H.), Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany.
Christian ApitzDepartment of Pediatric Cardiology, University Hospital for Pediatrics and Adolescent Medicine Ulm, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The number of adults with congenital heart defects (ACHDs) is steadily increasing and is about 360,000 in Germany. Congenital heart defect (CHD) is often associated with pulmonary hypertension (PH), which sometimes develops early in untreated CHD. Despite timely treatment of CHD, PH not infrequently persists, redevelops in older age, and is associated with significant morbidity and mortality. The revised European Society of Cardiology (ESC)/European Respiratory Society (ERS) 2022 guidelines for the diagnosis and treatment of PH represent a significant contribution to the optimized care of those affected. However, the topic of "adults with congenital heart defects" is treated only relatively superficially in this context. After the first part commenting on a broad range of topics like definition, epidemiology, classification, diagnostics, genetics, risk stratification and follow-up, and gender aspects, the second part focuses on supportive therapy, special situations (pregnancy, contraception, non-cardiac surgery), targeted pharmacotherapy, organ transplantation, special management [shunt lesion, left ventricular (LV) disease, univentricular hearts], interventions, intensive care, ACHD follow-up, and future perspective. In the present article, therefore, this topic is commented on from the perspective of congenital cardiology. By examining these aspects in detail, this article aims to fill the gaps in the existing guidelines and provide a more thorough understanding from the perspective of congenital cardiology.

Indexed as

congenital heart defect (CHD)Eisenmenger syndrome (ES)Pulmonary arterial hypertension (PAH)

Identifiers

PMID39513142
PMCPMC11538840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.