ReviewBrain communications2024
Cerebral hyperactivation across the Alzheimer's disease pathological cascade.
Review in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Task-based fMRI brain activation in mild cognitive impairment and Alzheimer's disease: an ALE meta-analysis.GeroScience · 2026Pooled it
- Exergame as medicine? Functional brain adaptations linked to cognitive changes in neurocognitive disorders: exploratory randomized controlled trial.GeroScience · 2026Article
- Article
- Alterations in topological and dynamical parameters correlate with disease biomarkers and neuropsychological scores in prodromic stages of dementia.Scientific reports · 2026Article
- Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- The emergence of neuropsychiatric symptoms in preclinical Alzheimer's disease: An emotion regulation perspective.Neuron · 2026Review
- Dynamic recovery of piriform cortex function and its impact on cognitive processing speed following mild COVID-19.BMC neurology · 2026Article
- Blood phosphorylated tau elevation as a biomarker in immunoglobulin light chain and transthyretin amyloidosis.Nature medicine · 2026Article
- Maintaining and regaining episodic memory in Alzheimer disease: a circuit-based perspective.Nature reviews. Neurology · 2026Review
- Dysfunction of the episodic memory network in the Alzheimer's disease cascade.Nature communications · 2026Article
- Restoration of gamma center frequency via personalized entrainment marks cognitive preservation in early Alzheimer's disease.GeroScience · 2026Article
- The electrophysiological basis of resting-state fMRI hyperconnectivity in early Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Neural plasticity impairment in chronic post-surgical hypoparathyroidism: a cross-sectional and prospective pilot study.Endocrine connections · 2026Article
- Chronic Aerobic Exercise Alleviates Amyloid-induced Capillary Dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.Alzheimer's research & therapy · 2026Article
- Excitation-inhibition homeostasis in Alzheimer's disease: a selective multiscale review of mechanisms, sex differences, and therapeutic opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
- Gut-brain health effects of PREbiotics in older adults with suspected COgnitive DEcline: design of the PRECODE randomised placebo-controlled trial.Frontiers in nutrition · 2026Article
- Amyloid-beta relates to default and attention network connectivity during working memory retrieval.Brain communications · 2026Article
- Elevated functional magnetic resonance imaging activity in cognitively normal participants predicts future dementia.Brain communications · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Neuronal dysfunction in specific brain regions or across distributed brain networks is a known feature of Alzheimer's disease. An often reported finding in the early stage of the disease is the presence of increased functional MRI (fMRI) blood oxygenation level-dependent signal under task conditions relative to cognitively normal controls, a phenomenon known as 'hyperactivation'. However, research in the past decades yielded complex, sometimes conflicting results. The magnitude and topology of fMRI hyperactivation patterns have been found to vary across the preclinical and clinical spectrum of Alzheimer's disease, including concomitant 'hypoactivation' in some cases. These incongruences are likely due to a range of factors, including the disease stage at which the cohort is examined, the brain areas or networks studied and the fMRI paradigm utilized to evoke these functional abnormalities. Additionally, a perennial question pertains to the nature of hyperactivation in the context of Alzheimer's disease. Some propose it reflects compensatory mechanisms to sustain cognitive performance, while others suggest it is linked to the pathological disruption of a highly regulated homeostatic cycle that contributes to, or even drives, disease progression. Providing a coherent narrative for these empirical and conceptual discrepancies is paramount to develop disease models, understand the synergy between hyperactivation and the Alzheimer's disease pathological cascade and tailor effective interventions. We first provide a comprehensive overview of functional brain changes spanning the course from normal ageing to the clinical spectrum of Alzheimer's disease. We then highlight evidence supporting a close relationship between fMRI hyperactivation and
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