ArticleCell reports. Physical science2024
Amino acid-dependent phase equilibrium and material properties of tetrapeptide condensates.
Article in Cell reports. Physical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Backbone Hydrogen Bonding as a Determinant of Condensate Material States.Journal of the American Chemical Society · 2026Article
- Programmable Coacervates Based on Minimalist Sticker-Spacer Frameworks: Chemical Design, Functions, and Emerging Applications.ACS applied materials & interfaces · 2026Review
- Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Measuring bridging forces in protein-DNA condensates.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Correlated Segments of Intrinsically Disordered Proteins as Drivers of Homotypic Phase Separation.JACS Au · 2025Article
- Atomistic molecular dynamics simulations of intrinsically disordered proteins.Current opinion in structural biology · 2025Review
- The rheology and interfacial properties of biomolecular condensates.Biophysical reviews · 2025Review
- Live-cell quantification reveals viscoelastic regulation of synapsin condensates by α-synuclein.Science advances · 2025Article
- Decoding biomolecular condensate dynamics: an energy landscape approach.PLoS computational biology · 2025Article
- Article
- Predicting the sequence-dependent backbone dynamics of intrinsically disordered proteins.eLife · 2024Article
- Predicting the Sequence-Dependent Backbone Dynamics of Intrinsically Disordered Proteins.bioRxiv : the preprint server for biology · 2024Article
- Fundamental Aspects of Phase-Separated Biomolecular Condensates.Chemical reviews · 2024Review
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Authors and funding
5 authors.
Funding
Abstract
The rules of how amino acids dictate the physical properties of biomolecular condensates are still incomplete. Here, we study condensates formed by tetrapeptides of the form XXssXX. Eight peptides form four types of condensates at different concentrations and pHs: droplets (X = F, L, M, P, V, and A), amorphous dense liquids (X = L, M, P, V, and A), amorphous aggregates (X = W), and gels (X = I, V, and A). The peptides exhibit differences in phase equilibrium and material properties, including a 368-fold range in the threshold concentration for phase separation and a 3,856-fold range in viscosity. All-atom molecular dynamics simulations provide physical explanations of these results. The present work also reveals widespread critical behaviors-including critical slowing down manifested by amorphous dense liquids and critical scaling obeyed by fusion speed-with broad implications for condensate functions.
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