Evidence map›Paper›PMID 39513033›Full record

ArticleJournal of translational internal medicine2024

Inetetamab for injection in combination with vinorelbine weekly or every three weeks in HER2-positive metastatic breast cancer: A multicenter, randomized, phase II clinical trial.

Xiying Shao, Ning Xie, Zhanhong Chen, Xinshuai Wang, Wenming Cao, Yabing Zheng, Hua Yang, Jian Huang, Shaoping Chen, Lu Gan and 4 more

Abstract read
In one paragraph

Article in Journal of translational internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiying ShaoDepartment of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China.
Ning XieMedical Department of Breast Cancer, Hunan Cancer Hospital, Changsha 410013, Hunan Province, China.
Zhanhong ChenDepartment of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China.
Xinshuai WangThe 1st Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
Wenming CaoDepartment of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China.
Yabing ZhengDepartment of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China.
Hua YangDepartment of Medical Oncology, Affiliated Hospital of Hebei University; Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Shijiazhuang 071000, Hebei Province, China.
Jian HuangDepartment of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China.
Shaoping ChenDepartment of Oncology, Dongying People's Hospital, Dongying 257091, Shandong Province, China.
Lu GanThe First Hospital of Chongqing Medical University Affiliated Hospital. Medical Oncology, Chongqing 400016, China.
Xiuli YangThe First Affiliated Hospital of Nanyang Medical College, Nanyang 473007, Henan Province, China.
Yuru ChenShandong Provincial Hospital Heze Hospital (Heze Municipal Hospital) Oncology Department, Heze 274000, Shandong Province, China.
Quchang OuyangMedical Department of Breast Cancer, Hunan Cancer Hospital, Changsha 410013, Hunan Province, China.ORCID https://orcid.org/0000-0003-1233-6081
Xiaojia WangDepartment of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China.ORCID https://orcid.org/0000-0001-5043-2459

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: We aimed to investigate the pharmacokinetics, safety, efficacy, and immunogenicity of different dosing regimens (weekly and every three weeks) of inetetamab in combination with vinorelbine in human epidermal growth factor receptor 2 (HER2)+ patients with metastatic breast cancer who had received one or more chemotherapy regimens. Methods: HER2+ patients with metastatic breast cancer who had received one or more chemotherapy regimens were included. Eligible patients received inetetamab administered weekly or every three weeks in combination with vinorelbine injection chemotherapy. Pharmacokinetics, safety, efficacy, and immunogenicity were compared between the groups. Results: Sixty HER2+ patients were randomized into a single-week administration group ( Conclusion: There were slight differences in the mean C

Indexed as

efficacyimmunogenicitymetastatic breast cancerpharmacokineticssafety

Identifiers

PMID39513033
PMCPMC11538898

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.