Evidence map›Paper›PMID 39512864›Full record

ArticleNpj viruses2024

Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters.

Kim Handrejk, Katharina S Schmitz, Edwin J B Veldhuis Kroeze, Laura L A van Dijk, Peter van Run, Bart Haagmans, Anne Moscona, Matteo Porotto, Rik L de Swart, Rory D de Vries and 1 more

Abstract read
In one paragraph

Article in Npj viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kim HandrejkDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Katharina S SchmitzDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Edwin J B Veldhuis KroezeDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Laura L A van DijkDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Peter van RunDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Bart HaagmansDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Anne MosconaDepartment of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY USA.
Matteo PorottoDepartment of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY USA.
Rik L de SwartDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Rory D de VriesDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Melanie RissmannDepartment of Viroscience, Erasmus MC, Rotterdam, the Netherlands.

Funding

Engineering protease-resistant antiviral peptide inhibitors for SARS-CoV-2R01AI160961 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOSCONA, ANNE · 2021 to 2025
$3.6M
Fusion inhibitors that block host-to-host transmission of SARS-CoV-2R01AI160953 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI POROTTO, MATTEO · 2021 to 2025
$3.6M
NIAID NIH HHS R01 AI160953NIAID NIH HHS R01 AI160961
6 · The paper itself

Abstract

As SARS-CoV-2 continues to evolve antigenically to escape vaccine- or infection-induced immunity, suitable animal models are needed to study novel interventions against viral variants. Syrian hamsters are often used because of their high susceptibility to SARS-CoV-2 and associated tissue damage in the respiratory tract. Here, we established a direct-contact transmission model for SARS-CoV-2 Omicron BA.5 in hamsters. First, we determined whether 10

Indexed as

Drug screeningVirology

Identifiers

PMID39512864
PMCPMC11537969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.