Evidence map›Paper›PMID 39512841›Full record

ArticleFASEB bioAdvances2024

TMEM182 inhibits myocardial differentiation of human iPS cells by maintaining the activated state of Wnt/β-catenin signaling through an increase in ILK expression.

Hirofumi Morihara, Shunichi Yokoe, Shigeo Wakabayashi, Shinji Takai

Abstract read
In one paragraph

Article in FASEB bioAdvances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Exploring the Regulation ofJournal of developmental biology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hirofumi MoriharaDepartment of Pharmacology, Faculty of Medicine Osaka Medical and Pharmaceutical University Takatsuki Japan.ORCID https://orcid.org/0009-0005-0985-0161
Shunichi YokoeDepartment of Pharmacology, Faculty of Medicine Osaka Medical and Pharmaceutical University Takatsuki Japan.ORCID https://orcid.org/0009-0006-0069-8447
Shigeo WakabayashiDepartment of Pharmacology, Faculty of Medicine Osaka Medical and Pharmaceutical University Takatsuki Japan.ORCID https://orcid.org/0009-0000-7768-5851
Shinji TakaiDepartment of Pharmacology, Faculty of Medicine Osaka Medical and Pharmaceutical University Takatsuki Japan.ORCID https://orcid.org/0000-0003-3963-3983

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transmembrane protein 182 (TMEM182) is notably abundant in muscle and adipose tissue, but its role in the heart remains unknown. This study examined the contribution of TMEM182 in the differentiation of human induced pluripotent stem cells (hiPSCs) into cardiomyocytes. For this, we generated hiPSCs overexpressing TMEM182 in a doxycycline-inducible manner and induced their differentiation into cardiomyocytes. On Day 12 of differentiation, expression of the cardiomyocyte markers,

Indexed as

hiPSCsmyocardial differentiationTMEM182

Identifiers

PMID39512841
PMCPMC11539028

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.