ArticleFrontiers in genetics2024
Association between gout and kidney stone: results from mendelian randomization and the NHANES study.
Article in Frontiers in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Long-term exposure to ambient air pollution and an increased risk of hyperuricemia.Clinical rheumatology · 2026Article
- Deciphering the association between uric acid and kidney stones: insights into the mediating roles of BMI and serum iron: a cross-sectional study based on NHANES 2007-2018.International journal of surgery (London, England) · 2026Article
- Accuracy and readability of LLM-generated responses for gout management: a benchmark study based on ACR guidelines.Clinical rheumatology · 2026Article
- Prevalence of Urinary Stones and Their Associated Risk Factors in the Jazan Region of Saudi Arabia.Cureus · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
Background: Kidney stones are a common urologic disease with an increasing incidence year by year, and there are similar influences between gout status and kidney stone incidence. Therefore the contribution of gout status to the incidence of kidney stones is unclear. The aim of this study was to investigate the relationship between gout status and kidney stones and to further explore the causal relationship by Mendelian randomization (MR) analysis. Method: An epidemiologic study of 49,693 participants in the 2009-2018 National Health and Nutrition Examination Survey (NHANES) was conducted to examine the association between the two. The causal relationship between gout status and kidney stones was assessed by Mendelian randomization analysis of data from the GWAS database. Result: A total of 28,742 participants were included in the NHANES analysis. We found that gout status was associated with an increased risk of kidney stones [odds ratio (OR) = 1.45 (95%CI, 1.243-1.692); Conclusion: There may be an association between gout status and kidney stone risk. This finding requires further large-sample studies and adequate follow-up.
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