Evidence map›Paper›PMID 39512756›Full record

ArticleFrontiers in endocrinology2024

Unequal causality between autoimmune thyroiditis and inflammatory bowel disease: a Mendelian randomization study.

Siyang Bai, Yunfeng Yu, Xinyu Yang, Gang Hu, Jingyi Wu, Keke Tong, Yuman Yin, Juan Deng, Cong Chen, Chuanchuan Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siyang Bai *Department of Digestive Endoscopy, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Yunfeng Yu *Department of Digestive Endoscopy, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Xinyu YangSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Gang HuDepartment of Digestive Endoscopy, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Jingyi WuThe Third School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Keke TongSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Yuman YinSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Juan DengSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Cong ChenSchool of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Chuanchuan TanDepartment of Digestive Endoscopy, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aims to analyze the causal relationship between autoimmune thyroiditis (AIT) and inflammatory bowel disease (IBD) using bidirectional Mendelian randomization (MR). Methods: Single nucleotide polymorphisms were obtained from FinnGen. Exposure-outcome causality was assessed using inverse variance weighted, MR-Egger, and weighted median. MR-Egger intercept, Cochran's Q, and leave-one-out sensitivity analysis were used to evaluate horizontal pleiotropy, heterogeneity, and robustness, respectively. Results: Forward analysis revealed no significant association between AIT and the risk of ulcerative colitis (UC) (odds ratio [OR] 1.008, 95% confidence interval [CI] 0.986 to 1.03, Conclusion: This MR analysis suggests that CD, but not UC, is a risk factor for AIT, whereas AIT is not associated with the risk of IBD. Proactive prevention and treatment of CD can help mitigate the risk of AIT.

Indexed as

Inflammatory Bowel DiseasesMendelian Randomization AnalysisPolymorphism, Single NucleotideThyroiditis, AutoimmuneCausalityColitis, UlcerativeCrohn DiseaseGenetic Predisposition to DiseaseHumansRisk Factorsautoimmune thyroiditisCrohn’s diseaseFinnGeninflammatory bowel diseaseMendelian randomizationulcerative colitis

Identifiers

PMID39512756
PMCPMC11540656

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.