ArticleJournal of the Electrochemical Society2024
Electrochemical HOCl Production Modeling for an Electrochemical Catheter.
Article in Journal of the Electrochemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Electrochemical Catheter Hub Operated by a Wearable Micropotentiostat Prevents Acinetobacter baumannii Infection In Vitro.Biotechnology and bioengineering · 2025Article
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Authors and funding
5 authors.
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Abstract
Hypochlorous acid (HOCl) is a strong oxidizing agent that damages cells by interacting with lipids, nucleic acids, sulfur-containing amino acids, and membrane components. It is an endogenous substance produced by the immune system to protect mammals from pathogens. Previously, we developed an HOCl-generating electrochemical catheter (e-catheter) and demonstrated its ability to prevent central line-associated bloodstream infections. The e-catheter is an electrochemical system consisting of two parts - an e-hub and a tube. Working, counter, and reference electrodes are placed in the e-hub, which contains 0.9% NaCl as an electrolyte. Although a prototype of this device has shown activity against pathogens, it is helpful to understand the factors influencing associated electrochemical/chemical processes to optimize design and efficacy. A mathematical model could predict factors influencing HOCl generation and distribution in the catheter and could aid in optimizing these devices. Here, we developed an Electrochemical Hypochlorous Acid Production (EHAP) model to predict factors influencing electrochemical generation and distribution of HOCl in e-catheters, including polarization time, diffusion of HOCl into the e-catheter, operational voltage, working electrode length, and surface area.
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