ArticleFrontiers in cardiovascular medicine2024
Causal relationship between hypothyroidism and coronary atherosclerotic cardiovascular disease: a bidirectional two-sample Mendelian randomization.
Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Thyroid dysfunction and cardiovascular disease.European heart journal · 2026Review
- Article
- Cardiomyopathies of endocrine origin: A state-of-the-art review.World journal of cardiology · 2025Review
- Hypothyroidism consequent to thyroidectomy is associated with elevated remnant lipoproteins and cholesterol enrichment of triglyceride-rich lipoproteins: an observational study.Lipids in health and disease · 2025Observational
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7 authors.
Funding
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Abstract
Background: Epidemiological and observational studies demonstrate a comorbid relationship between hypothyroidism and atherosclerotic cardiovascular disease (ASCVD). The nature and direction of this causal relationship, however, remain unclear. Objective: This study aims to elucidate the causal relationship between hypothyroidism and ASCVD using a bidirectional Mendelian randomization approach. Method: Single nucleotide polymorphisms (SNPs) associated with hypothyroidism were identified and selected as genetic instrumental variables from aggregated data of genome-wide association studies (GWAS). The outcome of interest, ASCVD, included seven conditions: coronary artery disease (CAD), angina pectoris (AP), myocardial infarction (MI), ischemic stroke (IS), and subtypes IS-large artery atherosclerosis (IS-LAA), IS-small vessels (IS-SV), and peripheral artery disease (PAD). MR analysis employed multiple methods-chiefly inverse variance weighting (IVW), along with MR Egger, weighted median, and weighted mode-to assess causality. Cochrane's Result: GWAS pooled data yielded 122 SNPs as potential instrumental variables for hypothyroidism. Forward MR analysis, using the IVW method, indicated hypothyroidism as a risk factor for CAD (OR = 2.34, 95% CI = 1.39-3.94, Conclusion: The marked association between hypothyroidism and CAD, AP, MI, and IS suggests that thyroid function assessment could be integral to preventing and diagnosing specific ASCVD types. This underscores the need for individuals with hypothyroidism to be proactive regarding ASCVD risk factors. A balanced Th1/Th2 and Th17/Treg ratio may offer a novel strategy in preventing CAD and enhancing the prognosis for hypothyroid patients.
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