ArticleFrontiers in cardiovascular medicine2024
Elevated postoperative systemic immune-inflammation index associates with acute kidney injury after cardiac surgery: a large-scale cohort study.
Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Systemic immune-inflammation index as a risk factor for acute kidney injury in patients with neonatal jaundice.Translational pediatrics · 2026Article
- Preoperative systemic immune inflammation index predicts early complications and 30-day mortality after heart valve surgery: a retrospective cohort study.BMC anesthesiology · 2026Article
- Article
- Differentiated associations of inflammatory indices with laboratory-defined organ injury/involvement and hospitalization length in pediatric respiratory tract infections.Frontiers in pediatrics · 2026Article
- Beyond ACEF: integrating biomarkers and intraoperative factors for enhanced AKI prediction post-SAVR.Renal failure · 2025Article
- Acute kidney injury: pathogenesis and therapeutic interventions.Molecular biomedicine · 2025Review
- New Insights in Assessing AKI 3 Risk Factors and Predictors Associated with On-Pump Surgical Aortic Valve Replacement.Diagnostics (Basel, Switzerland) · 2025Article
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Abstract
Objective: To investigate whether postoperative systemic immune-inflammation index (SII) is associated with acute kidney injury (AKI) after cardiac surgery. Methods: We included patients undergoing cardiac surgery from the Medical Information Mart for Intensive Care-Ⅳ database to conduct a retrospective cohort study. The outcomes are AKI, severe AKI, and 30-day mortality after cardiac surgery. Analytical techniques including receiver operating characteristic (ROC) analysis, restricted cubic splines (RCS), and multivariable logistic regression were used to assess the association between SII and outcomes. Sensitivity analyses using inverse probability of treatment weighting (IPTW) and the E-value were conducted to validate the stability of the results. Results: 3,799 subjects were included in this study. We used ROC to calculate an optimal cutoff value for predicting AKI after cardiac surgery, and subsequently patients were divided into two groups based on the cutoff value (Low SII: ≤ 949 × 10 Conclusion: Elevated SII was independently associated with a higher risk of AKI in adults undergoing cardiac surgery. The potential causal relationship between postoperative SII and cardiac surgery associated AKI warrants prospective research.
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