Evidence map›Paper›PMID 39512363›Full record

ArticleRare tumors2024

The efficacy of combination immunotherapy with ipilimumab plus nivolumab in metastatic myxofibrosarcoma.

Foteini Kalofonou, Andrea Napolitano, Charlotte Benson, Aisha Miah, Shane Zaidi, Daniel Lindsay, Khin Thway, Robin L Jones

Abstract readCase Reports
In one paragraph

Article in Rare tumors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Adoptive T-Cell Therapy in Sarcomas.Current oncology reports · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Foteini KalofonouSarcoma Unit, The Royal Marsden Hospital and Institute of Cancer Research, London, UK.ORCID https://orcid.org/0009-0006-4068-3856
Andrea NapolitanoSarcoma Unit, The Royal Marsden Hospital and Institute of Cancer Research, London, UK.ORCID https://orcid.org/0000-0002-7509-1555
Charlotte BensonSarcoma Unit, The Royal Marsden Hospital and Institute of Cancer Research, London, UK.
Aisha MiahSarcoma Unit, The Royal Marsden Hospital and Institute of Cancer Research, London, UK.
Shane ZaidiSarcoma Unit, The Royal Marsden Hospital and Institute of Cancer Research, London, UK.
Daniel LindsaySarcoma Unit, The Royal Marsden Hospital and Institute of Cancer Research, London, UK.
Khin ThwaySarcoma Unit, The Royal Marsden Hospital and Institute of Cancer Research, London, UK.
Robin L JonesSarcoma Unit, The Royal Marsden Hospital and Institute of Cancer Research, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the case of a patient with Myxofibrosarcoma (MFS), a mesenchymal type of soft tissue sarcoma (STS) and the response to combination immunotherapy with anti PD-1 and anti-CTLA-4 therapy, following disease progression after Standard chemotherapy (SACT) and Radiotherapy (RT). We have shown a timeline of treatment and responses, as well as the overall safety profile and the management of immunotherapy related adverse events. This study demonstrates the potential of checkpoint inhibitors as therapeutic agents in the treatment of MFS.

Indexed as

combination immunotherapyimmunotherapy outcomeipilimumabmyxofibrosarcomanivolumabrare tumors

Identifiers

PMID39512363
PMCPMC11542115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.