Evidence map›Paper›PMID 39512362›Full record

ArticleMicro & nano letters2011

Leukocyte rolling on engineered nanodot surfaces.

X Lin-Schmidt, A S W Ham, M L Reed, M B Lawrence, B P Helmke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micro & nano letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

X Lin-SchmidtDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
A S W HamDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
M L ReedDepartment of Electrical and Computer Engineering, University of Virginia, Charlottesville, VA 22908, USA.
M B LawrenceDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
B P HelmkeDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.

Funding

Engineering an Atherosclerosis-Resistant EndotheliumR01HL080956 · NHLBI · UNIVERSITY OF VIRGINIA · PI SCHWARTZ, MARTIN A · 2007 to 2011
$3.6M
Flow-Induced Cytoskeletal Mechanics in Endothelial CellsR01HL071958 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HELMKE, BRIAN P · 2004 to 2007
$1.0M
NHLBI NIH HHS R01 HL071958NHLBI NIH HHS R01 HL080956
6 · The paper itself

Abstract

Leukocyte rolling on the blood vessel wall represents the first step in the process of inflammation. In this study, nanofabricated substrates were designed with two different sets of feature size and spacing to mimic the expected distribution of discrete molecular adhesion patches on the surfaces of endothelial cells lining the blood vessel wall. P-selectin was attached to these nanopatterned dots, and the rolling behaviour of HL60 cells was analysed as a function of wall shear stress. When wall shear stress was less than 1 dyne/cm

Identifiers

PMID39512362
PMCPMC11542712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.