Evidence map›Paper›PMID 39512105›Full record

ArticleHistology and histopathology2025

Impact of 6-OHDA injection and microtrauma in the rat

Joshua A Roldán-Kalil, Sara E Vendrell-Gonzalez, Natalia Espinosa-Ponce, Jadier Colón-Vasques, Jescelica Ortiz-Rivera, Vassiliy Tsytsarev, Janaina M Alves, Mikhail Inyushin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joshua A Roldán-KalilDepartment of Physiology, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico.
Sara E Vendrell-GonzalezDepartment of Microbiology and Immunology, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico.
Natalia Espinosa-PonceDepartment of Microbiology and Immunology, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico.
Jadier Colón-VasquesDepartment of Physiology, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico.
Jescelica Ortiz-RiveraDepartment of Physiology, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico.
Vassiliy TsytsarevDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Janaina M AlvesDepartment of Microbiology and Immunology, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico.
Mikhail InyushinDepartment of Physiology, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico. mikhail.inyushin@uccaribe.edu.

Funding

Build-up of beta-amyloid in the brain in Parkinson's disease-SupplementSC3GM143983 · NIGMS · UNIVERSIDAD CENTRAL DEL CARIBE · PI INYUSHIN, MIKHAIL · 2022 to 2025
$606k
NIGMS NIH HHS SC3 GM143983NIH Grant SC3GM143983Translational Research Supported by the US Department of Education P031S160068
6 · The paper itself

Abstract

Amyloid beta peptides (Aβ) are key indicators of Alzheimer's disease and are also linked to cognitive decline in Parkinson's disease (PD) and other neurodegenerative disorders. This study explored the accumulation of Aβ in a standard 6-Hydroxydopamine (6-OHDA) model of PD. We unilaterally injected 6-OHDA into the

Indexed as

Amyloid beta-PeptidesOxidopamineSubstantia NigraAnimalsDisease Models, AnimalDopaminergic NeuronsMaleRatsRats, WistarAmyloid beta-PeptidesOxidopamine

Identifiers

PMID39512105
PMCPMC11925656

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.