Evidence map›Paper›PMID 39511948›Full record

ReviewMuscle & nerve2025

An overview of the non-procedural treatment options for peripheral neuropathic pain.

Evan R Zeldin, Adam R Goddard, Maxwell S Boyle, Renee L Madathil, Erick Rosenvall, Kajri A Majithia, Eric J Morrison

Abstract readReview
In one paragraph

Review in Muscle & nerve, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Evan R ZeldinDivision of Physical Medicine and Rehabilitation, Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0002-6511-7491
Adam R GoddardDivision of Physical Medicine and Rehabilitation, Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Maxwell S BoyleDivision of Physical Medicine and Rehabilitation, Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Renee L MadathilDepartments of Psychiatry and Surgery, University of Rochester Medical Center, Rochester, New York, USA.
Erick RosenvallDepartment of Physical Medicine and Rehabilitation, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.
Kajri A MajithiaDivision of Physical Medicine and Rehabilitation, Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Eric J MorrisonDepartment of Physical Medicine and Rehabilitation, University of Rochester Medical Center, Rochester, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral neuropathic pain is common in patients with peripheral nerve injury and can significantly impact both their function and quality of life. There is a wide variety of non-interventional treatment approaches, including pharmacologic therapy, physical/occupational therapy, modalities (therapeutic, mechanical, thermal, etc.), psychology, and lifestyle modification. First line pharmacologic therapy for peripheral neuropathic pain includes gabapentinoids, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors. Other classes of medications, such as topical treatments, opioids, and cannabinoids, have more limited usefulness in treatment but remain part of a treatment regimen. Physical and occupational therapy, psychological interventions, and lifestyle medicine are important adjuncts in the treatment and prevention of future peripheral neuropathic pain. The strength of the evidence supporting each intervention varies, with that for pharmacologic intervention being the strongest. A combination of these options tailored to the individual needs of the patient likely will result in the best treatment outcome for peripheral neuropathic pain.

Indexed as

NeuralgiaPain ManagementHumansPhysical Therapy Modalitieschronic neuropathic painnerve injuryneuropathic painnociceptionperipheral nerve injury

Identifiers

PMID39511948
PMCPMC11998966

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.