Evidence map›Paper›PMID 39511924›Full record

ArticleCancer2025

Sexual dysfunction among long-term survivors of Hodgkin lymphoma.

Emily Hanzlik, Noah D Sabin, Tomoko Yoshida, Angela Delaney, Lu Xie, Himani Darji, Deokumar Srivastava, Daniel A Mulrooney, Melissa M Hudson, Kevin R Krull and 1 more

Abstract read
In one paragraph

Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emily HanzlikPediatric Medicine Division of Neurology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0009-0002-8743-7186
Noah D SabinDiagnostic Imaging, St Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-7584-2574
Tomoko YoshidaEpidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Angela DelaneyPediatric Medicine Division of Endocrinology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Lu XieBiostatistics, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Himani DarjiDepartment of Quantitative Sciences Unit, Stanford University, Palo Alto, California, USA.
Deokumar SrivastavaBiostatistics, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Daniel A MulrooneyEpidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Melissa M HudsonEpidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kevin R KrullPsychology and Biobehavioral Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-0476-7001
Raja B KhanPediatric Medicine Division of Neurology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
The St. Jude Lifetime CohortU01CA195547 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HUDSON, MELISSA M, NESS, KIRSTEN KIMBERLIE · 2015 to 2024
$14.9M
Brain Integrity in Survivors of Childhood Cancer Treated with Thoracic RadiationR01CA174794 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KRULL, KEVIN R, SABIN, NOAH D. · 2013 to 2017
$3.1M
American Lebanese Syrian Associated CharitiesNCI NIH HHS P30 CA021765NCI NIH HHS R01 CA174794NCI NIH HHS U01 CA195547
6 · The paper itself

Abstract

backgroundSurvival rates from childhood cancer continue to increase, with an ongoing interest in long-term survivorship. Although infertility and gonadal failure are well recognized in Hodgkin lymphoma (HL) survivors, sexual dysfunction is less studied. The objective of this study was to compare the prevalence of sexual dysfunction in HL survivors with that in matched community controls.

methodsLong-term survivors of HL (n = 186; female, 51.61%; mean age at diagnosis. 14.41 years [range, 3.01-22.60 years]; current mean ± standard deviation age, 36.73 ± 7.93 years) and matched community controls (n = 182; female, 50.55%; mean ± standard deviation age, 36.41 ± 9.02 years) completed a comprehensive, in-person clinical assessment, laboratory battery, and the International Index of Erectile Function or the Female Sexual Function Index questionnaire.

resultsMale survivors had increased levels of erectile dysfunction (18.89% vs. 6.67%; p = .0239) but indicated no difference in sexual desire. Female survivors had a higher prevalence of sexual dysfunction compared with female controls (46.88% vs. 15.22%; p < .0001) and an increased prevalence of moderate-to-severe loss of sexual desire (38.04% vs. 23.26%; p = .0361). Female survivors with sexual dysfunction indicated increased levels of anxiety (p = .0184), depression (p = .0153), and worse physical and mental health (p = .0141 and p = .0419, respectively). Male survivors with erectile dysfunction had higher rates of anxiety and impaired physical health (p = .0147 and p = .0266, respectively).

conclusionsSexual dysfunction was prevalent in this childhood and adolescent Hodgkin lymphoma survivor cohort and was associated with effects on quality of life. Health care providers must recognize the need for screening and intervention in this group to hopefully contribute to improved overall quality of life.

Indexed as

Cancer SurvivorsHodgkin DiseaseSexual Dysfunction, PhysiologicalAdolescentAdultCase-Control StudiesChildChild, PreschoolErectile DysfunctionFemaleHumansMaleMiddle AgedPrevalenceQuality of LifeSexual Dysfunctions, Psychologicalcancer survivorshipHodgkin lymphomalong‐term follow‐upquality of lifesexual dysfunction

Identifiers

PMID39511924
PMCPMC11695136

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.