Evidence map›Paper›PMID 39511872›Full record

ArticleEuropean journal of immunology2024

Rise of a CD27

François Brinas, Nicolas Sailliet, Gaëlle Tilly, Laurence Delbos, Clarisse Kerleau, Magali Giral, Nicolas Degauque, Sophie Brouard, Richard Danger

Abstract read
In one paragraph

Article in European journal of immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

François BrinasNantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), UMR 1064, ITUN, Nantes, France.ORCID 0009-0001-7446-3580
Nicolas SaillietNantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), UMR 1064, ITUN, Nantes, France.ORCID 0000-0002-0232-1663
Gaëlle TillyNantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), UMR 1064, ITUN, Nantes, France.
Laurence DelbosNantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), UMR 1064, ITUN, Nantes, France.ORCID 0000-0002-4320-0681
Clarisse KerleauNantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), UMR 1064, ITUN, Nantes, France.ORCID 0000-0002-1487-5743
Magali GiralNantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), UMR 1064, ITUN, Nantes, France.ORCID 0000-0001-7641-1592
Nicolas DegauqueNantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), UMR 1064, ITUN, Nantes, France.ORCID 0000-0003-2990-3513
Sophie BrouardNantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), UMR 1064, ITUN, Nantes, France.ORCID 0000-0002-6398-1315
Richard DangerNantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), UMR 1064, ITUN, Nantes, France.ORCID 0000-0002-5058-795X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of immunosuppressive treatment is required to prevent rejection events, even a long time after kidney transplantation despite rare recipients achieving long-term graft stability without the need for immunosuppressive treatment, called operationally tolerant patients (TOLs). We comprehensively investigate the immune system of long-term IS recipients (LTTs) and TOLs to highlight their shared and unique immune features. Blood immune cell phenotyping was performed by spectral cytometry. Samples from 34 individuals were analyzed, including 6 LTTs, 8 TOLs, 10 stable patients at 1 year posttransplantation (STAs), and 10 healthy volunteers. B cells differed between LTTs and TOLs with a decreased total B-cell frequency and the acquisition of a memory phenotype in LTTs whereas a naive phenotype is maintained in TOLs. The frequencies of IgD

Indexed as

Immunoglobulin DKidney TransplantationTumor Necrosis Factor Receptor Superfamily, Member 7AdultAgedB-LymphocytesB-Lymphocyte SubsetsCD11c AntigenFemaleGraft RejectionHumansImmunologic MemoryImmunosuppression TherapyImmunosuppressive AgentsMaleMemory B CellsCD11c AntigenImmunoglobulin DImmunosuppressive AgentsTumor Necrosis Factor Receptor Superfamily, Member 7Atypical B cellsB cellsCD11cKidney transplantationLong term stable patient

Identifiers

PMID39511872
PMCPMC11628921

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.