Evidence map›Paper›PMID 39511792›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

Hypothyroidism Predicts Fistula Development Following Salvage Oropharyngectomy.

Andrew D P Prince, Zachary M Huttinger, Molly E Heft-Neal, Steven B Chinn, Kelly M Malloy, Chaz L Stucken, Keith A Casper, Mark E P Prince, Matthew E Spector, Andrew J Rosko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew D P PrinceDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9359-7739
Zachary M HuttingerDepartment of Otolaryngology, The Ohio State University College of Medicine, Columbus, OH, USA.
Molly E Heft-NealDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Steven B ChinnDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Kelly M MalloyDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Chaz L StuckenDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Keith A CasperDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Mark E P PrinceDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Matthew E SpectorDepartment of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Andrew J RoskoProMedica Physicians Ear, Nose and Throat-Sylvania, Sylvania, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importancePrevious work demonstrated postoperative hypothyroidism adversely affects wound healing in salvage laryngectomy. Currently, no studies have evaluated the association between wound healing and hypothyroidism in patients undergoing salvage oropharyngectomy.

objectiveThe primary objective was studying hypothyroidism and other factors associated with oropharyngocutaneous fistula development and fistula requiring reoperation within 30 days after salvage oropharyngectomy.

designRetrospective cohort study.

settingTertiary academic center.

participantsAll patients who underwent salvage oropharyngectomy for recurrent or second primary oropharyngeal squamous cell carcinoma between 2001 and 2017 after radiation or chemoradiation. Patients with no preoperative thyroid-stimulating hormone (TSH) values were excluded. EXPOSURES: Salvage oropharyngectomy for recurrent or second primary oropharyngeal squamous cell carcinoma. MAIN OUTCOMES MEASURES: The principle explanatory variable was postoperative hypothyroidism, defined as TSH greater than 5.5 mIU/L. Univariate, bivariate, and binary logistical regression multivariate analysis was performed.

resultsFifty-three patients met inclusion criteria, 37.7% of patients developed hypothyroidism, 18.9% developed a fistula, and 9.4% required an operation to manage the fistula. Postoperative fistula rate was 35% among hypothyroid patients, which was significantly greater than among euthyroid patients (9.1%; CONCLUSIONS AND RELEVANCE: Postoperative hypothyroidism in patients who underwent salvage oropharyngectomy can predict fistula development and fistula requiring operative management. This study supports the treatment of hypothyroidism after surgery to reduce wound complications.

Indexed as

Cutaneous FistulaHypothyroidismOropharyngeal NeoplasmsPostoperative ComplicationsSalvage TherapyAgedCarcinoma, Squamous CellFemaleFistulaHumansMaleMiddle AgedPharyngeal DiseasesPharyngectomyReoperationRetrospective Studiesfistulahead and neck cancerhypothyroidismsalvage oropharyngectomysalvage surgerywound healing

Identifiers

PMID39511792
PMCPMC11544655

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.