ArticleNMR in biomedicine2025
High-resolution perfusion imaging in rodents using pCASL at 9.4 T.
Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Robust MR-AIV: A Systematic Study of Robustness Improvement and Sensitivity Analysis of MR-AIV.bioRxiv : the preprint server for biology · 2026Article
- Vascular smooth muscle cell loss, but not neuroinflammation, drives cerebrovascular reactivity impairment in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Bidirectional crusher gradient method to estimate the labeling efficiency of pseudo-continuous arterial spin labeling MRI in mice.Magnetic resonance in medicine · 2026Article
- Article
- Magnetic resonance imaging cerebral blood perfusion measurement in awake mice.Journal of neuroscience methods · 2025Article
- A quality assurance protocol for reliable and reproducible multi-TI arterial spin labeling perfusion imaging in rat livers.Magma (New York, N.Y.) · 2025Article
- Vascular and metabolic responses to elevated circulating PDGF-BB in mice: A multiparametric MRI study.Health and metabolism · 2025Article
- High-resolution perfusion imaging in rodents using pCASL at 9.4 T.NMR in biomedicine · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Adequate perfusion is critical for maintaining normal brain function and aberrations thereof are hallmarks of many diseases. Pseudo-Continuous Arterial Spin Labeling (pCASL) MRI enables noninvasive quantitative perfusion mapping without contrast agent injection and with a higher signal-to-noise ratio (SNR) than alternative methods. Despite its great potential, pCASL remains challenging, unstable, and relatively low-resolution in rodents - especially in mice - thereby limiting the investigation of perfusion properties in many transgenic or other relevant rodent models of disease. Here, we address this gap by developing a novel experimental setup for high-resolution pCASL imaging in mice and combining it with the enhanced SNR of cryogenic probes. We show that our new experimental setup allows for optimal positioning of the carotids within the cryogenic coil, rendering labeling reproducible. With the proposed methodology, we managed to increase the spatial resolution of pCASL perfusion images by a factor of 15 in mice; a factor of 6 in rats is gained compared to the state of the art just by virtue of the cryogenic coil. We also show that the improved pCASL perfusion imaging allows much better delineation of specific brain areas, both in healthy animals as well as in rat and mouse models of stroke. Our results bode well for future high-definition pCASL perfusion imaging in rodents.
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