Evidence map›Paper›PMID 39511676›Full record

ArticleVeterinary research2024

Protective efficacy of a recombinant adenovirus expressing novel dual F and HN proteins of bovine parainfluenza virus type 3.

Jiaqi Zhang, Jinbo Wu, Qing Zhu, Xiangyue Huang, Zhaohui Zhang, Chenxi Zhu, Gunan Deng, Ajia Ake, Yuanzhen Ma, Chunsai He and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiaqi ZhangCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Jinbo WuAnimal Husbandry Science Institute of ABa Autonomous Prefecture, Hongyuan, 624400, China.
Qing ZhuCenter for Animal Disease Control and Prevention, Ganzi Tibetan Autonomous Prefectue, Kangding, 626000, China.
Xiangyue HuangAnimal Husbandry Science Institute of ABa Autonomous Prefecture, Hongyuan, 624400, China.
Zhaohui ZhangCenter for Animal Disease Control and Prevention, Ganzi Tibetan Autonomous Prefectue, Kangding, 626000, China.
Chenxi ZhuCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Gunan DengCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Ajia AkeCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Yuanzhen MaCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Chunsai HeCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Rui GuoCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Hua YueCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Lan LanAnimal Husbandry Science Institute of Ganzi Tibetan Autonomous Prefecture, Kangding, 626000, China. 88240273@qq.com.
Bin ZhangCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China. binovy@sina.com.ORCID http://orcid.org/0000-0002-3893-906X

Funding

14th Five-Year Plan National Key Research and Development Project 2021YFD1600203Fundamental Research Funds for the Central Universities, Southwest Minzu University ZYN2023111Program Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System SCCXTD-2020-18Sichuan Transfer Payment Technology Project 210015Wellcome Trust 220022
6 · The paper itself

Abstract

Bovine parainfluenza virus type 3 (BPIV3) is a viral respiratory pathogen that infects cattle and causes significant economic losses. We generated a recombinant adenovirus called rHAd5-F + HN by expressing the fusion (F) and hemagglutinin-neuraminidase (HN) glycoprotein of BPIV3 using the human adenovirus serotype 5 (rHAd5). We evaluated its effects on humoral and cellular immune responses in mice (n = 45) and calves (n = 9). Serum antibody responses were assessed by enzyme-linked immunosorbent assay (ELISA), hemagglutination inhibition (HI), and neutralising antibodies (NAb). After boosting immunity with rHAd5-F + HN, mice produced significantly higher levels of antibodies against the BPIV3 genotype A and genotype C strains. The production of antibodies exceeded those produced by adenoviruses rHAd5-F and rHAd5-HN, which express the F and HN glycoprotein, respectively. The percentages of splenic CD3

Indexed as

Cattle DiseasesHN ProteinParainfluenza Virus 3, BovineRespirovirus InfectionsViral Fusion ProteinsAdenoviridaeAnimalsAntibodies, ViralCattleFemaleImmunity, CellularImmunity, HumoralMiceMice, Inbred BALB CVaccines, SyntheticViral VaccinesAntibodies, ViralF protein, parainfluenza virus 3HN ProteinVaccines, SyntheticViral Fusion ProteinsViral Vaccinesadenovirus vector vaccineBovine parainfluenza virus type 3F and HN proteinsprotection efficacy

Identifiers

PMID39511676
PMCPMC11545272

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.