ArticleBMC pediatrics2024
Relationship between lactate levels and 28-day mortality in pediatric sepsis: results from the pediatric intensive care database.
Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026.Intensive care medicine · 2026Pooled it
- Pediatric Trauma Score (PTS) combined with blood lactate measurement provides clinical treatment guidance and prognosis prediction for children with compound injuries: a prospective study.European journal of pediatrics · 2026Trial
- Pathogenic spectrum, antibiotic resistance, and risk factors for 28-day mortality in pediatric bloodstream infection-associated sepsis: a 10-year retrospective cohort study.Microbiology spectrum · 2026Article
- Management of Sepsis and Septic Shock in Children: Surviving Sepsis Campaign International Guidelines 2026.Indian pediatrics · 2026Review
- Prehospital lactate, transfer time, and early mortality across emergency diagnostic categories.Critical care (London, England) · 2026Observational
- Lactate to creatinine ratio: just another biomarker?Pediatric research · 2026Review
- Care Pathway and Outcomes in Pediatric Septic Shock: A Narrative Review from Emergency Department Recognition to PICU Management.Children (Basel, Switzerland) · 2026Review
- Neonatal sepsis and cardiovascular dysfunction II: assessment.Pediatric research · 2026Review
- Association between serum endothelial glycocalyx biomarkers and prognosis in paediatric sepsis.BMC infectious diseases · 2026Observational
- Article
- Shock-Stratified Prognostic Performance of Lactate and Procalcitonin in Pediatric Sepsis In-Hospital Mortality; A Retrospective Cohort Study.Archives of academic emergency medicine · 2026Article
- Metabolomics of Sepsis and Acute Kidney Injury in Infants and Children: Current Challenges in Prevention, Diagnosis, and Management.Infectious diseases and therapy · 2025Review
- Clinical value of albumin-corrected anion gap combined with lactate dehydrogenase in predicting sepsis-associated liver injury in children: a single-center retrospective cohort study.BMC pediatrics · 2025Article
- Relationship between preoperative high arterial blood lactate level and delirium after deep brain stimulation surgery in Parkinson's disease.Frontiers in aging · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThis study aimed to investigate the relationship between serum lactate levels at admission to the intensive care unit (ICU) and the clinical outcomes of children with sepsis.
methodsWe used the Pediatric Intensive Care (PIC) database to identify 288 pediatric patients with sepsis. We analyzed the relationship between lactate levels and hospital and ICU mortality in sepsis by establishing a segmented multivariable Cox regression model. We also conducted subgroup analysis as well as analyzed the restricted cubic spline curves.
resultsAfter adjusting for all potential confounding factors, an increase of 1 mmol/L in lactate levels was found to be associated with an 17% rise in the 28-day hospital mortality risk among sepsis patients (HR: 1.17, 95% CI: 1.08-1.27, P = 0.0002). When considering lactate as a categorical variable, the mortality risk of patients with lactate levels ≥ 2.2 mmol/L was significantly increased (HR: 3.61, 95% CI: 1.24-10.54, P = 0.0189). The restricted cubic spline curve analysis revealed a nonlinear correlation between lactate and 28-day mortality, with an inflection point at 2.2 mmol/L. Similar findings were also observed in the assessment of secondary outcomes.
conclusionsOur study demonstrates a non-linear correlation between lactate levels and 28-day mortality in pediatric sepsis, with a critical threshold of 2.2mmol/l for lactate levels in septic patients. Early assessment of lactate levels is recommended for children with sepsis to facilitate prompt intervention and mitigate the risk of fatality.
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