ArticleBMC musculoskeletal disorders2024
Abnormally low serum albumin levels are associated with abnormal bone mineral density and osteoporotic fractures: a retrospective studies.
Article in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Immune-inflammatory and metabolic signatures for osteoporosis risk stratification in primary Sjögren's syndrome: development and internal validation of an interpretable machine-learning model.Frontiers in immunology · 2026Article
- Osteoporotic fractures prediction in Chinese postmenopausal women: a machine learning-based multi-dimensional approach.Frontiers in endocrinology · 2026Article
- Hip Fracture as a Systemic Disease in Older Adults: A Narrative Review on Multisystem Implications and Management.Medical sciences (Basel, Switzerland) · 2025Review
- Neutrophil-to-albumin ratio: a novel predictor of osteoporosis in rheumatoid arthritis.Frontiers in immunology · 2025Article
- Biochemical and Demographical Differences in Atypical vs. Typical Femoral Fractures: A 10-Year Experience Across Two Centers.International journal of endocrinology · 2025Article
- Article
- Advanced lung cancer inflammation index as a diagnostic indicator of bone turnover in osteoporotic fracture patients: a non-linear analysis.Frontiers in endocrinology · 2025Article
- The association between the albumin to globulin ratio and thoracic spine bone mineral density in adolescents: NHANES 2011-2016.Frontiers in nutrition · 2025Article
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7 authors.
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Abstract
backgroundMany studies have indicated that abnormal bone mineral density (BMD) is related to abnormal liver and kidney function, but the effect of serum albumin level on abnormal BMD and osteoporotic fracture is still controversial. The aim of this retrospective study was to investigate the effects of serum albumin levels on abnormal BMD and osteoporotic fractures.
methodsThe study included 538 patients through the electronic medical records of inpatients and outpatients stored at Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology. A multivariate logistic regression model was employed to test the relationship between serum albumin levels and abnormal BMD, and the effect of serum albumin levels on osteoporotic fractures was verified through the U test. Correlation between age, sex, kidney stones, coronary heart disease, hypertension, diabetes, fatty liver disease, haemoglobin (HB), mean corpuscular haemoglobin concentration (MCHC), platelets (PLT), platelet distribution width (PDW), lymphocytes (LYMP), alanine aminotransferase (ALT), total protein (TP), albumin (ALB), uric acid (UA), total bilirubin (TBIL), total cholesterol (TC), high-density lipoprotein (HDL) and abnormal BMD were analysed by logistic regression modelling after excluding confounding factors.
resultsThe ALB level in osteoporotic patients was 41.70 (36.40-45.00) g/L, which was significantly lower than those in the normal BMD and reduced BMD groups. The odds ratio (OR) (95% confidence interval [CI]) between the osteoporosis and normal BMD groups was 0.445 (0.394-0.502); the OR (95% CI) between the osteoporosis and reduced BMD groups was 0.395 (0.341-0.459). In the subgroup analysis by whether or not a fracture was present, the OR (95% CI) was 0.073 (0.045-0.119).
conclusionsALB is a protective factor against osteoporosis and osteoporotic fractures, suggesting that it may have the potential to predict osteoporosis onset and fractures.
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