Evidence map›Paper›PMID 39511449›Full record

SynthesisMolecular psychiatry2025

Peripartum allopregnanolone blood concentrations and depressive symptoms: a systematic review and individual participant data meta-analysis.

Georgios Schoretsanitis, Lauren M Osborne, Inger Sundström-Poromaa, Elizabeth S Wenzel, Jennifer L Payne, Corrado Barbui, Chiara Gastaldon, Kristina M Deligiannidis

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Biomarkers of reproductive psychiatric disorders.The British journal of psychiatry : the journal of mental science · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Georgios SchoretsanitisNorthwell Health, Department of Psychiatry, the Zucker Hillside Hospital, Glen Oaks, NY, USA. georgios.schoretsanitis@bli.uzh.ch.ORCID 0000-0002-3851-4117
Lauren M OsborneDepartments of Obstetrics and Gynecology and of Psychiatry, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0003-0979-7901
Inger Sundström-PoromaaDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-2491-2042
Elizabeth S WenzelDepartment of Psychology, University of Illinois, Chicago, IL, USA.
Jennifer L PayneDepartment of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-0006-1199
Corrado BarbuiWHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.ORCID 0000-0003-1073-9282
Chiara GastaldonWHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.
Kristina M DeligiannidisNorthwell Health, Department of Psychiatry, the Zucker Hillside Hospital, Glen Oaks, NY, USA.ORCID 0000-0001-7439-2236

Funding

Relationships between Neuroactive Steroids, GABA and Glutamate MRS and Connectivity of the Default Mode Network in Postpartum DepressionR01MH120313 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DELIGIANNIDIS, KRISTINA MARIE · 2020 to 2024
$2.7M
Neuroimaging epigenetics of prospective postpartum depression biomarkersR01MH104262 · NIMH · JOHNS HOPKINS UNIVERSITY · PI KAMINSKY, ZACHARY AARON · 2014 to 2018
$2.4M
Biological Mechanisms of Perinatal AnxietyK23MH110607 · NIMH · JOHNS HOPKINS UNIVERSITY · PI OSBORNE, LAUREN M · 2017 to 2021
$985k
Neuroendocrine and Neuroimaging Endophenotypes in Postpartum DepressionK23MH097794 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DELIGIANNIDIS, KRISTINA MARIE · 2013 to 2017
$897k
NIMH NIH HHS K23 MH097794NIMH NIH HHS K23 MH110607NIMH NIH HHS R01 MH104262NIMH NIH HHS R01 MH120313
6 · The paper itself

Abstract

Neuroactive steroids including allopregnanolone are implicated in the pathophysiology of peripartum depressive symptoms (PDS). We performed a systematic review searching PubMed/Embase/PsychInfo/Cinhail through 08/2023 (updated in 07/2024), and conducted a random-effects meta-analysis of studies comparing allopregnanolone blood concentrations in women with versus without PDS at various timepoints during the 2

Indexed as

DepressionPeripartum PeriodPregnanoloneAdultDepression, PostpartumFemaleHumansPostpartum PeriodPregnancyPregnanolone

Identifiers

PMID39511449
PMCPMC11835716

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.