Evidence map›Paper›PMID 39511421›Full record

ArticleNPJ precision oncology2024

Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology.

Siddhi Ramesh, Emma Dyer, Monica Pomaville, Kristina Doytcheva, James Dolezal, Sara Kochanny, Rachel Terhaar, Casey J Mehrhoff, Kritika Patel, Jacob Brewer and 11 more

Abstract read
In one paragraph

Article in NPJ precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Siddhi RameshDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Emma DyerDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Monica PomavilleDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0008-0498-5544
Kristina DoytchevaAnatomic Pathology Department of Oklahoma University Medical Center, Oklahoma City, OK, USA.
James DolezalGeisinger Cancer Institute, Danville, PA, USA.ORCID http://orcid.org/0000-0002-6788-7203
Sara KochannyDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Rachel TerhaarPritzker School of Medicine, University of Chicago, Chicago, IL, USA.
Casey J MehrhoffIntermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA.
Kritika PatelCancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, WA, USA.ORCID http://orcid.org/0009-0007-3569-294X
Jacob BrewerApplied Data Science Program, University of Chicago, Chicago, IL, USA.
Benjamin KusswurmApplied Data Science Program, University of Chicago, Chicago, IL, USA.
Arlene NaranjoChildren's Oncology Group Statistics and Data Center, Department of Biostatistics, University of Florida, Gainesville, FL, USA.
Hiroyuki ShimadaDepartment of Pathology and Pediatrics, Stanford University, Stanford, CA, USA.
Nicole A CiprianiDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Aliya N HusainDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Peter PytelDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Elizabeth A SokolDivision of Hematology, Oncology, and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-1787-6901
Susan L CohnDepartment of Pediatrics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5749-7650
Rani E GeorgeDepartment of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA.
Alexander T PearsonDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2801-7456
Mark A ApplebaumDepartment of Pediatrics, University of Chicago, Chicago, IL, USA. mapplebaum@bsd.uchicago.edu.

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1M
COG U24 Funding 2026-2027U24CA196173 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mignon Lee-Cheun Loh, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$62.5M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014599NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA196173U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30CA014599
6 · The paper itself

Abstract

A deep learning model using attention-based multiple instance learning (aMIL) and self-supervised learning (SSL) was developed to perform pathologic classification of neuroblastic tumors and assess MYCN-amplification status using H&E-stained whole slide images from the largest reported cohort to date. The model showed promising performance in identifying diagnostic category, grade, mitosis-karyorrhexis index (MKI), and MYCN-amplification with validation on an external test dataset, suggesting potential for AI-assisted neuroblastoma classification.

Identifiers

PMID39511421
PMCPMC11544094

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.