ArticleNature plants2024
Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation.
Article in Nature plants, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- N-glycosylation code diversifies paralogous chitinases to balance plant immunity and growth.Nature plants · 2026Article
- Pathogen-Induced Cell Wall Remodeling and Immune Signaling in Plants.The plant pathology journal · 2026Review
- Peptide hormones in shaping root system architecture and environmental adaptation: Current advances and translational perspectives.Plant communications · 2026Review
- Cross-ribbon conformation defines peptide recognition in SCREW/CTNIP-NUT/HSL3 signalling.Nature plants · 2026Article
- A tomato MIK2-clade receptor is involved in the perception of a Fusarium-derived elicitor.The New phytologist · 2026Article
- A disulfide bond sculpts the CTNIP4 phytocytokine fold for recognition by the receptor kinase HSL3.Nature plants · 2026Article
- Small Peptides, Smart Plants: The Emerging Significance of SCOOP Signalling.Plant, cell & environment · 2026Review
- Disulfide-bond-driven neck-ring-like conformation mediates SCREW recognition in plant immunity.Nature plants · 2026Article
- Advances in the roles of SCOOP peptides and the receptor-like kinase MIK2 in plant stress responses.Plant cell reports · 2026Review
- A copper-dependent redox-based hydrogen peroxide perception in plants.Nature communications · 2026Article
- Processing and release of endogenous immunogenic peptide signals.The Plant journal : for cell and molecular biology · 2026Review
- Structural insights into glycan recognition by plant immune receptors: a comparative perspective with animal innate immune systems.The Plant journal : for cell and molecular biology · 2026Review
- The size of apoplastic peptides: Do the cell wall matrix and cell-surface receptors matter?Plant communications · 2026Article
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- The transformative power of structural predictions with AI in plant science.The Plant journal : for cell and molecular biology · 2026Review
- Peptide signaling at the intersection of growth, nutrient sensing, and stress responses.The Plant journal : for cell and molecular biology · 2026Review
- AtLYK4 is the major chitin receptor in Arabidopsis with N-glycosylation and ligand-interacting residues orchestrating chitin perception.Science China. Life sciences · 2026Article
- The Arabidopsis deNADding Enzyme DXO1 Modulates the Plant Immunity Response.Plant, cell & environment · 2026Article
- Genetic Diversity, Predictive Protein Structures, and Interaction Networks of Cysteine-Rich Receptor-Like Kinases inComputational and structural biotechnology journal · 2026Article
- β-sheet stabilization of the island domain underlies ligand-induced LRR-RP activation of plant immune signaling.Nature communications · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Funding
Abstract
Ligand-induced receptor and co-receptor heterodimerization is a common mechanism in receptor kinase (RK) signalling activation. SERINE-RICH ENDOGENOUS PEPTIDEs (SCOOPs) mediate the complex formation of Arabidopsis RK MIK2 and co-receptor BAK1, triggering immune responses. Through structural, biochemical and genetic analyses, we demonstrate that SCOOPs use their SxS motif and adjacent residues to bind MIK2 and the carboxy-terminal GGR residues to link MIK2 to BAK1. While N-glycosylation of plant RKs is typically associated with protein maturation, plasma membrane targeting and conformation maintenance, a surprising revelation emerges from our crystal structural analysis of MIK2-SCOOP-BAK1 complexes. Specific N-glycans on MIK2 directly interact with BAK1 upon SCOOP sensing. The absence of N-glycosylation at the specific site in MIK2 neither affects its subcellular localization and protein accumulation in plant cells nor alters its structural conformation, but markedly reduces its affinity for BAK1, abolishing SCOOP-triggered immune responses. This N-glycan-mediated receptor and co-receptor heterodimerization occurs in both Arabidopsis and Brassica napus. Our findings elucidate the molecular basis of SCOOP perception by the MIK2-BAK1 immune complex and underscore the crucial role of N-glycans in plant receptor-coreceptor interactions and signalling activation, shaping immune responses.
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