Evidence map›Paper›PMID 39511225›Full record

ArticleNature communications2024

HuD impairs neuromuscular junctions and induces apoptosis in human iPSC and Drosophila ALS models.

Beatrice Silvestri, Michela Mochi, Darilang Mawrie, Valeria de Turris, Alessio Colantoni, Beatrice Borhy, Margherita Medici, Eric Nathaniel Anderson, Maria Giovanna Garone, Christopher Patrick Zammerilla and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Oxidative stress in neurodegeneration: from a simple insult to a dynamic regulator.Redox report : communications in free radical research · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Beatrice SilvestriDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.
Michela MochiDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.
Darilang MawrieDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Valeria de TurrisCenter for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy.ORCID 0000-0003-0872-185X
Alessio ColantoniDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.
Beatrice BorhyDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID 0009-0005-5115-7942
Margherita MediciDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.
Eric Nathaniel AndersonDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Maria Giovanna GaroneStem Cell Medicine Department, Murdoch Children's Research Institute, Parkville, VIC, Australia.ORCID 0000-0002-2101-4474
Christopher Patrick ZammerillaDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Marco SimulaDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.
Monica BallarinoDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-8595-7105
Udai Bhan PandeyDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0002-6267-0179
Alessandro RosaDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy. alessandro.rosa@uniroma1.it.ORCID 0000-0001-9999-7223

Funding

Cellular and Molecular Mechanisms of FUS-related Amyotrophic Lateral SclerosisR01NS081303 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PANDEY, UDAI B · 2013 to 2023
$3.6M
Human Frontier Science Program (HFSP) LT0024/2022-LMinistero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) 2022BYB33LMinistero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) CN00000041NINDS NIH HHS R01 NS081303Sapienza Università di Roma (Sapienza University of Rome) RM12117A5DE7A45BSapienza Università di Roma (Sapienza University of Rome) RP123188EC9F2349Wellcome Trust
6 · The paper itself

Abstract

Defects at the neuromuscular junction (NMJ) are among the earliest hallmarks of amyotrophic lateral sclerosis (ALS). According to the "dying-back" hypothesis, NMJ disruption not only precedes but also triggers the subsequent degeneration of motoneurons in both sporadic (sALS) and familial (fALS) ALS. Using human induced pluripotent stem cells (iPSCs), we show that the RNA-binding protein HuD (ELAVL4) contributes to NMJ defects and apoptosis in FUS-ALS. HuD overexpression mimics the severe FUS

Indexed as

Amyotrophic Lateral SclerosisApoptosisDisease Models, AnimalELAV-Like Protein 4Induced Pluripotent Stem CellsMotor NeuronsNeuromuscular JunctionRNA-Binding Protein FUSAnimalsDrosophilaDrosophila melanogasterDrosophila ProteinsFemaleHumansMaleMutationDrosophila ProteinsELAV-Like Protein 4FUS protein, humanRNA-Binding Protein FUS

Identifiers

PMID39511225
PMCPMC11544248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.