Evidence map›Paper›PMID 39511145›Full record

ArticleNature communications2024

Structural insights into the agonist selectivity of the adenosine A

Hidetaka S Oshima, Akiko Ogawa, Fumiya K Sano, Hiroaki Akasaka, Tomoyoshi Kawakami, Aika Iwama, Hiroyuki H Okamoto, Chisae Nagiri, Fan-Yan Wei, Wataru Shihoya and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. From empirical screening to lipid trolling: the evolution of extrahelical allosteric modulators of AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  3. Article
  4. Review
  5. Bitopic AJournal of medicinal chemistry · 2025
    Article
  6. Article
  7. Review
  8. 2-Substituted (N)-Methanocarba AACS pharmacology & translational science · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hidetaka S OshimaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.ORCID 0009-0000-0341-707X
Akiko OgawaDepartment of Modomics Biology and Medicine, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan.
Fumiya K SanoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-8965-788X
Hiroaki AkasakaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-2118-0912
Tomoyoshi KawakamiDepartment of Modomics Biology and Medicine, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan.
Aika IwamaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Hiroyuki H OkamotoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Chisae NagiriDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Fan-Yan WeiDepartment of Modomics Biology and Medicine, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan. fanyan.wei.d3@tohoku.ac.jp.ORCID 0000-0002-4843-724X
Wataru ShihoyaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan. wtrshh9@gmail.com.ORCID 0000-0003-4813-5740
Osamu NurekiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan. nureki@bs.s.u-tokyo.ac.jp.ORCID 0000-0003-1813-7008

Funding

Japan Agency for Medical Research and Development (AMED) JP19am01011115MEXT | Japan Society for the Promotion of Science (JSPS) 21H05037
6 · The paper itself

Abstract

Adenosine receptors play pivotal roles in physiological processes. Adenosine A

Indexed as

AdenosineAdenosine A3 Receptor AgonistsCryoelectron MicroscopyReceptor, Adenosine A3Adenosine-5'-(N-ethylcarboxamide)AnimalsHEK293 CellsHumansIsopentenyladenosineLigandsAdenosineAdenosine-5'-(N-ethylcarboxamide)Adenosine A3 Receptor AgonistsIsopentenyladenosineLigandsN-methyladenosineReceptor, Adenosine A3

Identifiers

PMID39511145
PMCPMC11544091

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.