Trial reportBritish journal of anaesthesia2025
Effect of exercise prehabilitation on quality of recovery after cardiac surgery: a single-centre randomised controlled trial.
Trial report in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- The Long-Term Impact of a Teleprehabilitation Programme on Modifiable Risk Factors and Quality of Life After Cardiac Surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026Trial
- Esketamine-Based Opioid-Free versus Opioid-Based Anesthesia for Recovery Quality After Laparoscopic Transabdominal Preperitoneal Repair: A Randomized Noninferiority Trial.Drug design, development and therapy · 2026Trial
- Effect of Different Doses of Esketamine on Postoperative Recovery in Patients Undergoing Gynecologic Laparoscopic Surgery, a Randomized, Double-Blind, Single-Center Clinical Study.Drug design, development and therapy · 2025Trial
- Impact of preoperative frailty and sarcopenia on short-term functional recovery after cardiac surgery in elderly patients: a prospective cohort study.The journal of nutrition, health & aging · 2026Article
- Global perspectives on prehabilitation: a commentary.Journal of anesthesia · 2026Article
- Refining the framework of cardiac prehabilitation: insights from the PREQUEL trial and beyond.Journal of thoracic disease · 2026Article
- Monitoring cardiac symptoms during teleprehabilitation prior to coronary artery bypass grafting: a digital cardiac counselling trial subanalysis.European heart journal. Digital health · 2026Article
- Prehabilitation Before Cardiac Surgery and Structural Heart Interventions: An Umbrella Review of Pooled Evidence.Journal of clinical medicine · 2026Review
- Cardiac prehabilitation: progress toward the who, what, when, where, and how.Journal of thoracic disease · 2026Article
- Prehabilitation in cardiac surgery.JTCVS open · 2026Article
- Review
- Exercise prehabilitation for brain health and sensory-cognitive function: Mechanistic insights into brain-body interactions.Experimental physiology · 2026Review
- The Evolution of Cardiac Rehabilitation from Supervised Models to New Frontiers in Digital Health.Journal of clinical medicine · 2026Review
- Article
- Comparing various frailty instruments for predicting adverse outcomes in older patients hospitalized with lower respiratory tract infections.The journal of nutrition, health & aging · 2026Article
- Impact of prehabilitation on patient-perceived quality of recovery after surgery: prospective cohort study.BJS open · 2025Article
- Dose-Response Effect of Physical Prehabilitation on Major Cardiac and Cerebrovascular Events and Disability Levels After Cardiac Surgery in Frail Patients.CHEST pulmonary · 2025Article
- Exercise-Based Prehabilitation Before Cardiac Surgery: A Systematic Review, Meta-Analysis, Meta-Regression, and Proposal for a Clinical Implementation Model.Journal of clinical medicine · 2025Review
- Comparative analgesic efficacy of erector spinae plane block versus quadratus lumborum block in laparoscopic renal cancer surgery: a double-blind randomized trial.Translational andrology and urology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical prehabilitation can enhance patient resilience to surgical stress, but its effects are unclear in vulnerable and frail patients. We aimed to determine the effect of a structured exercise prehabilitation programme on the quality of recovery after cardiac surgery in vulnerable and frail participants.
methodsThis single-blinded, parallel-arm, superiority, randomised controlled trial recruited patients with a Clinical Frailty Scale of 4-6 undergoing cardiac surgery. Patients were randomised to either physical prehabilitation (twice weekly) or standard care (control); both arms received standard perioperative care. The primary outcome was Quality of Recovery-15 (QoR-15) score on the third day after surgery. Secondary outcomes included major adverse cardiac and cerebrovascular events (MACCE), days alive and at home (DAH
resultsOf 164 randomised patients, 138 were included in the primary analysis (median age 64 [interquartile range 60-69] yr; 70% males). Compliance with the 5-week prehabilitation programme was high (82%), with no adverse exercise-induced events reported. There were no between-group differences in QoR-15 scores (median difference -3, 95% confidence interval [CI] -9 to 3), early and late MACCE, and DAH
conclusionsA 5-week programme of physical prehabilitation in predominately prefrail patients was safe, but it did not enhance quality of recovery scores after surgery. Prehabilitation resulted in a clinically meaningful decrease in disability scores at 90 days after surgery. CLINICAL
trial registrationChiCTR1800016098.
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