Evidence map›Paper›PMID 39510896›Full record

ReviewTrends in cancer2025

Metabolic landscape of disseminated cancer dormancy.

Stanislav Drapela, Bruna M Garcia, Ana P Gomes, Ana Luísa Correia

Abstract readReview
In one paragraph

Review in Trends in cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. The metabolic profiles of cancer stem cells.Stem cell research & therapy · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Recurrent Breast Cancer Cells Depend onbioRxiv : the preprint server for biology · 2025
    Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stanislav DrapelaDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Bruna M GarciaChampalimaud Research, Champalimaud Foundation, Lisbon, Portugal.
Ana P GomesDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address: ana.dasilvagomes@moffitt.org.
Ana Luísa CorreiaChampalimaud Research, Champalimaud Foundation, Lisbon, Portugal. Electronic address: analuisa.correia@research.fchampalimaud.org.

Funding

Epigenetic and metabolic bottlenecks of tumorigenesisR01CA279023 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Ana da silva Gomes · 2024 to 2026
$3.1M
Adaptations of breast cancer metastasis to the aging lungR21AG083720 · NIA · H. LEE MOFFITT CANCER CTR & RES INST · PI DA SILVA GOMES, ANA · 2023 to 2024
$463k
NCI NIH HHS R01 CA279023NIA NIH HHS R21 AG083720
6 · The paper itself

Abstract

Cancer dormancy is a phenomenon defined by the entry of cancer cells into a reversible quiescent, nonproliferative state, and represents an essential part of the metastatic cascade responsible for cancer recurrence and mortality. Emerging evidence suggests that metabolic reprogramming plays a pivotal role in enabling entry, maintenance, and exit from dormancy in the face of the different environments of the metastatic cascade. Here, we review the current literature to understand the dynamics of metabolism during dormancy, highlighting its fine-tuning by the host micro- and macroenvironment, and put forward the importance of identifying metabolic vulnerabilities of the dormant state as therapeutic targets to eradicate recurrent disease.

Indexed as

Neoplasm Recurrence, LocalNeoplasmsTumor MicroenvironmentAnimalsHumansNeoplasm Metastasisdormancymetabolismmetastasismetastatic microenvironment

Identifiers

PMID39510896
PMCPMC11981868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.