ArticleeNeuro2024
Ventral Pallidum Neurons Are Necessary to Generalize and Express Fear-Related Responding in a Minimal Threat Setting.
Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues.Neurobiology of stress · 2026Article
- Paraventricular thalamic inputs to the ventral pallidum shape reward seeking during threat and fear responding in extinction.Behavioral neuroscience · 2025Article
- Subcortical brain volume changes linked to concern of falling in multiple sclerosis: a structural MRI study.Journal of neurology · 2025Article
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Authors and funding
2 authors.
Funding
Abstract
Fear generalization is a hallmark of anxiety disorders. Experimentally, fear generalization can be difficult to dissociate from its counterpart, fear discrimination. Here, we use minimal threat learning procedures to reveal such a dissociation. We show that in Long-Evans rats, an auditory threat cue predicting footshock on 10% of trials produces a discriminated fear response that does not generalize to a neutral auditory cue. In contrast, even slightly higher footshock probabilities (30 and 20%) produce fear generalization. AAV-mediated, caspase-3 deletion of ventral pallidum neurons abolishes fear generalization and reduces threat cue responding during extinction. The ventral pallidum's contribution to fear generalization and extinction threat responding does not depend on inputs from the nucleus accumbens. The results demonstrate a minimal threat learning approach to dissociate fear discrimination from fear generalization and a novel role for the ventral pallidum in generalizing and expressing fear.
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