Evidence map›Paper›PMID 39510784›Full record

ArticleBMJ open2024

STRIVE pilot trial: a protocol for a multicentre pragmatic internal pilot randomised controlled trial of Structured TRaining to Improve fitness in a Virtual Environment (STRIVE) before surgery.

Daniel I McIsaac, Puneeta Tandon, Gurlavine Kidd, Karina Branje, Emily Hladkowicz, Julie Hallet, Duminda Nalaka Wijeysundera, Susan Lee, Margaret L McNeely, Monica Taljaard and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06042491 (The STRIVE Before Surgery Pilot Trial), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06042491 nacompletednot on this map

The STRIVE Before Surgery Pilot Trial: a Vanguard Pragmatic Multicenter Randomized Trial of Structured TRaining to Improve Fitness in a Virtual Environment (STRIVE) Before Surgery

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2024 to 2026Enrolled144ConditionsSurgery-Complications, Disability PhysicalArmsPrehabilitation intervention
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Prehabilitation for cancer surgery: a systematic review of qualitative literature from experienced stakeholders.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daniel I McIsaacAnaesthesiology and Pain Medicine, Ottawa Hospital Research Institute Clinical Epidemiology Programme, Ottawa, Ontario, Canada dmcisaac@toh.ca.ORCID http://orcid.org/0000-0002-8543-1859
Puneeta TandonDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Gurlavine KiddPatient Partner, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Karina BranjeDepartment of Anaesthesiology and Pain Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Emily HladkowiczDepartments of Anaesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
Julie HalletSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Duminda Nalaka WijeysunderaDepartment of Anaesthesia, St Michael's Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-5897-8605
Susan LeeDepartment of Anesthesiology, Pharmacology, and Therapeutics, UBC Faculty of Medicine, Vancouver, British Columbia, Canada.
Margaret L McNeelyPhysical Therapy, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0003-4376-4847
Monica TaljaardClinical Epidemiology Programme, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0002-3978-8961
Chelsia GillisSchool of Human Nutrition, McGill University, Montreal, Québec, Canada.
STRIVE Trial Investigators
Canadian Perioperative Anesthesia Clinical Trials Group (PACT)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHome-based, virtually-supported care models may represent the most efficient and scalable approach to delivering prehabilitation services. However, virtual approaches to prehabilitation are understudied. This manuscript describes the protocol for an internal pilot randomised controlled trial of a virtually-delivered, multimodal prehabilitation intervention. METHODS AND ANALYSIS: We will conduct a pragmatic, individual patient, internal pilot randomised controlled trial of home-based, virtually supported, multimodal prehabilitation compared with standard perioperative care in adults undergoing elective, inpatient thoracic, abdominal, pelvic and vascular surgery at five Canadian hospitals. Participants will be partially blinded; clinicians and outcome assessors will be fully blinded. The intervention consists of 3-12 weeks of a home-based, multimodal (exercise, nutrition and psychosocial support) prehabilitation programme supported through an online platform. The primary feasibility outcomes and their progression targets are (1) monthly recruitment of>6 participants at each centre, (2) intervention adherence of>75%, (3) retention of>90% of participants at the patient-reported primary outcome point of 30-days after surgery and (4) elicitation of patient, clinician and researcher-identified barriers to our pragmatic trial. A sample size of 144 participants will be adequate to estimate recruitment, adherence and retention rates with acceptable precision. All participants will be followed to either death or up to 1 year. As an internal pilot, if no substantive changes to the trial or intervention design are required, pilot participant outcome data will migrate, unanalysed by allocation, to the future full-scale trial. ETHICS AND DISSEMINATION: Ethical approval has been granted by Clinical Trials Ontario (Project ID: 4479) and our ethics review board (Protocol Approval #20230399-01T). Results will be disseminated through presentations at scientific conferences, peer-reviewed publications, partner organisations and engagement of social and traditional media. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov identifier NCT06042491. Protocol, V.1.2, dated 6 June 2024.

Indexed as

Preoperative ExerciseCanadaHumansMulticenter Studies as TopicPhysical FitnessPilot ProjectsPragmatic Clinical Trials as TopicVirtual RealityExerciseFeasibility StudiesPsychosocial InterventionSurgery

Identifiers

PMID39510784
PMCPMC11552010

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.