Evidence map›Paper›PMID 39510574›Full record

Observational studySaudi medical journal2024

BOLA family genes are the drivers and potential biomarkers of survival in kidney renal clear cell carcinoma patients.

Mohammed Alissa, Abdullah Alghamdi, Suad A Alghamdi, Mohammed A Alshehri, Meshari A Alsuwat, Mamdouh Allahyani, Ali G Alkhathami

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Saudi medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammed AlissaFrom the Department of Medical Laboratory (Alissa, A. Alghamdi, S. A. Alghamdi, Alshehri), College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, from the Department of Clinical Laboratory Sciences (Alsuwat, Allahyani), College of Applied Medical Sciences, Taif University, Taif, and from the Department of Clinical Laboratory Sciences (Alkhathami), College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.ORCID https://orcid.org/0000-0002-4045-0810
Abdullah AlghamdiFrom the Department of Medical Laboratory (Alissa, A. Alghamdi, S. A. Alghamdi, Alshehri), College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, from the Department of Clinical Laboratory Sciences (Alsuwat, Allahyani), College of Applied Medical Sciences, Taif University, Taif, and from the Department of Clinical Laboratory Sciences (Alkhathami), College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.
Suad A AlghamdiFrom the Department of Medical Laboratory (Alissa, A. Alghamdi, S. A. Alghamdi, Alshehri), College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, from the Department of Clinical Laboratory Sciences (Alsuwat, Allahyani), College of Applied Medical Sciences, Taif University, Taif, and from the Department of Clinical Laboratory Sciences (Alkhathami), College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.
Mohammed A AlshehriFrom the Department of Medical Laboratory (Alissa, A. Alghamdi, S. A. Alghamdi, Alshehri), College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, from the Department of Clinical Laboratory Sciences (Alsuwat, Allahyani), College of Applied Medical Sciences, Taif University, Taif, and from the Department of Clinical Laboratory Sciences (Alkhathami), College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.
Meshari A AlsuwatFrom the Department of Medical Laboratory (Alissa, A. Alghamdi, S. A. Alghamdi, Alshehri), College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, from the Department of Clinical Laboratory Sciences (Alsuwat, Allahyani), College of Applied Medical Sciences, Taif University, Taif, and from the Department of Clinical Laboratory Sciences (Alkhathami), College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.
Mamdouh AllahyaniFrom the Department of Medical Laboratory (Alissa, A. Alghamdi, S. A. Alghamdi, Alshehri), College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, from the Department of Clinical Laboratory Sciences (Alsuwat, Allahyani), College of Applied Medical Sciences, Taif University, Taif, and from the Department of Clinical Laboratory Sciences (Alkhathami), College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.
Ali G AlkhathamiFrom the Department of Medical Laboratory (Alissa, A. Alghamdi, S. A. Alghamdi, Alshehri), College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, from the Department of Clinical Laboratory Sciences (Alsuwat, Allahyani), College of Applied Medical Sciences, Taif University, Taif, and from the Department of Clinical Laboratory Sciences (Alkhathami), College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo analyze the diagnostic and prognostic potential of the BOLA gene family in kidney renal clear cell carcinoma (KIRC).

methodsThis study is an observational study. The whole study was carried out at Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia from January to November 2023. As it involves in silico and in vitro methods, ethical consent was not required. Various in silico and molecular experimental techniques were employed in this study.

resultsSignificant up-regulation and hypomethylation of BOLA1, BOLA2, and BOLA3 were observed across 12 KIRC cell lines. Retrospective analysis of the cancer genome atlas program (TCGA)-KIRC cohorts confirmed hypomethylation of these genes in KIRC tissues. The cBioPortal analysis showed minimal genetic alterations, with amplification being the most common. Kaplan-Meier plotter data revealed that high BOLA1, BOLA2, and BOLA3 expression correlated with shorter overall survival and relapse-free survival in KIRC. Tumor-immune system interactions database analysis linked BOLA1 expression to immune and molecular subtypes. Gene silencing of BOLA1, BOLA2, and BOLA3 in 786-0 cells reduced cell growth and proliferation, enhancing wound healing capacity.

conclusionBOLA genes may serve as diagnostic and prognostic markers in KIRC, offering insights into therapeutic targets and disease progression.

Indexed as

Biomarkers, TumorCarcinoma, Renal CellKidney NeoplasmsCell Line, TumorCell ProliferationDNA MethylationHumansPrognosisRetrospective StudiesSurvival RateUp-RegulationBiomarkers, TumorBOLA genescarcinomagene expression regulationmolecular targeted therapyprognostic biomarkers

Identifiers

PMID39510574
PMCPMC11549612

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