Evidence map›Paper›PMID 39510555›Full record

ArticleThe European respiratory journal2025

Respiratory support and bronchopulmonary dysplasia in infants born at 22-26 weeks gestation in Sweden, 2004-2007 and 2014-2016.

Linn Löfberg, Thomas Abrahamsson, Lars J Björklund, Lena Hellström Westas, Aijaz Farooqi, Magnus Domellöf, Ulrika Ådén, Christian Gadsbøll, Karin Källén, David Ley and 8 more

Abstract read
In one paragraph

Article in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Toward precision for bronchopulmonary dysplasia: Moving past current definitions.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Linn LöfbergDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden linn.h.lofberg@gmail.com.ORCID https://orcid.org/0009-0003-9311-8285
Thomas AbrahamssonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Lars J BjörklundDepartment of Clinical Sciences, Lund, Paediatrics, Lund, Lund University and Skåne University Hospital, Lund, Sweden.ORCID https://orcid.org/0000-0002-7456-4189
Lena Hellström WestasDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Aijaz FarooqiDepartment of Clinical Sciences, Paediatrics, Umeå University, Umeå, Sweden.
Magnus DomellöfDepartment of Clinical Sciences, Paediatrics, Umeå University, Umeå, Sweden.
Ulrika ÅdénDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Christian GadsbøllDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID https://orcid.org/0009-0003-6356-6212
Karin KällénInstitution of Clinical Sciences, Department of Obstetrics and Gynaecology, Centre of Reproduction Epidemiology, Tornblad Institute, Lund University, Lund, Sweden.
David LeyDepartment of Clinical Sciences, Lund, Paediatrics, Lund, Lund University and Skåne University Hospital, Lund, Sweden.
Erik NormannDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Karin SävmanInstitute of Clinical Sciences, Department of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Anders ElfvinInstitute of Clinical Sciences, Department of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Stellan HåkanssonDepartment of Clinical Sciences, Paediatrics, Umeå University, Umeå, Sweden.
Mikael NormanDepartment of Neonatal Medicine, Karolinska University Hospital, Stockholm, Sweden.
Richard SindelarDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Fredrik SereniusDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Petra Um-BergströmDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-2715-2683

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOur aim was to evaluate if increased survival and new ventilation strategies were accompanied by a changed incidence of bronchopulmonary dysplasia (BPD) in Sweden over a decade.

methodsData from two Swedish population-based studies of live-born infants with gestational age (GA) 22-26 weeks, born during 2004-2007 (n=702) and 2014-2016 (n=885), were compared for survival, any BPD, moderate BPD and severe BPD and the composite outcomes of any BPD or death and severe BPD or death at 36 weeks postmenstrual age (PMA). Ventilation strategies and interventions were analysed. Any BPD was defined as the use of supplemental oxygen or any respiratory support at 36 weeks PMA, moderate BPD as nasal cannula with <30% oxygen and severe BPD as ≥30% oxygen, continuous positive airway pressure (CPAP) or mechanical ventilation.

resultsSurvival to 36 weeks PMA increased from 72% to 81% (p<0.001). Total days on mechanical ventilation increased from a median of 9 to 16 days (p<0.001). High-flow nasal cannula (HFNC) was introduced between the cohorts, and days of CPAP and HFNC increased from 44 to 50 days (p<0.001). Any BPD was unchanged at 65%

conclusionEven though an increased survival of infants born at 22-26 weeks GA was accompanied by an increased duration of invasive and non-invasive respiratory support, the incidence of any BPD remained unchanged, while severe BPD decreased in infants alive at 36 weeks PMA.

Indexed as

Bronchopulmonary DysplasiaRespiration, ArtificialCannulaContinuous Positive Airway PressureFemaleGestational AgeHumansIncidenceInfantInfant, NewbornInfant, PrematureMaleOxygen Inhalation TherapySweden

Identifiers

PMID39510555
PMCPMC11736309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.