Evidence map›Paper›PMID 39510416›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2024

Non-invasively measured myocardial torsional modulus: Comparison to invasive evaluation of diastolic function.

M Rifqi Aufan, Himanshu Gupta, Oleg F Sharifov, Gilbert J Perry, Thomas S Denney, Steven G Lloyd

Abstract readComparative Study
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Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

M Rifqi AufanDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham , Alabama USA.
Himanshu GuptaDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Valley Medical Group, Paramus, New Jersey, USA.
Oleg F SharifovDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Gilbert J PerryDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Thomas S DenneyDepartment of Electrical and Computer Engineering, Auburn University, Auburn, Alabama, USA.
Steven G LloydDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA. Electronic address: slloyd@uabmc.edu.

Funding

Left Ventricular Torsional Hysteresis: A Global Parameter for Diastolic FunctionR01HL104018 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUPTA, HIMANSHU · 2010 to 2014
$1.8M
NHLBI NIH HHS R01 HL104018
6 · The paper itself

Abstract

backgroundLeft ventricular (LV) diastolic function is a key determinant of cardiac output and impairments of diastolic function can lead to heart failure. Assessment of diastolic function is challenging due to several factors, including the load dependence of ventricular filling. We developed a method using cardiovascular magnetic resonance (CMR) imaging to model the untwisting motion of the LV as a viscoelastic damped oscillator to derive myocardial torsional modulus (µ) and frictional damping characteristics, and hypothesized that the torsional modulus would correlate with invasive measures of LV stiffness.

methodsTwenty-two participants who underwent invasive left heart catheterization (LHC) and CMR for the evaluation of chest pain were evaluated. µ and damping constants were determined by solving a system of equations using CMR-measured LV geometrical and angular displacement data during diastole. Time constant of pressure decay τ and chamber stiffness β were measured from invasive LHC and CMR-derived volume data as comparison metrics of diastolic function.

resultsµ was correlated with chamber stiffness constant β and time constant of pressure decay τ, derived from invasive measurement (R = 0.78, p < 0.001, and R = 0.51, p = 0.014, respectively). µ was also correlated with pre-A-wave diastolic pressure (0.67, p = 0.001).

conclusionWe propose a new method to objectively evaluate diastolic relaxation properties of the LV. This method may have promise to replace invasive, catheter-based assessment of diastolic function.

Indexed as

Cardiac CatheterizationDiastolePredictive Value of TestsTorsion, MechanicalVentricular Function, LeftAdultAgedBiomechanical PhenomenaFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleMiddle AgedModels, CardiovascularCMRDiastolic functionLV twistNon-invasive evaluationTorsional modulus

Identifiers

PMID39510416
PMCPMC11663766

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