Evidence map›Paper›PMID 39510243›Full record

Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2025

Automatic motion correction for myocardial blood flow estimation improves diagnostic performance for coronary artery disease in

Valerie Builoff, Cathleen Huang, Keiichiro Kuronuma, Chih-Chun Wei, Hidesato Fujito, Yuka Otaki, Serge D Van Kriekinge, Paul Kavanagh, Mark Lemley, Mark C Hyun and 3 more

Abstract readClinical Trial, Phase III
In one paragraph

Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Dynamic frame-by-frame motion correction forEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valerie BuiloffDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cathleen HuangDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Keiichiro KuronumaDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Cardiology, Nihon University, Tokyo, Japan.
Chih-Chun WeiDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Hidesato FujitoDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Cardiology, Nihon University Itabashi Hospital, Tokyo, Japan.
Yuka OtakiDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Radiology, Sakakibara Heart Institute, Tokyo, Japan.
Serge D Van KriekingeDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Paul KavanaghDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mark LemleyDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mark C HyunDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Marcelo Di CarliDivision of Cardiovascular Medicine, Department of Medicine, Heart and Vascular Center Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Daniel S BermanDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Piotr J SlomkaDepartments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Piotr.Slomka@cshs.org.

Funding

Integrating Artificial Intelligence for Optimal Analysis of CardiacPET/CTR01EB034586 · NIBIB · CEDARS-SINAI MEDICAL CENTER · PI DI CARLI, MARCELO F, SLOMKA, PIOTR J · 2022 to 2025
$2.9M
NIBIB NIH HHS R01 EB034586
6 · The paper itself

Abstract

backgroundMotion correction (MC) is critical for accurate quantification of myocardial blood flow (MBF) and flow reserve (MFR) from

methodsIn total, 231 patients who underwent invasive coronary angiography and rest/pharmacologic stress

resultsManual MC took 10 minutes per case (both stress and rest) on average, while automatic MC required <10 seconds. The area under the receiver operating characteristic curves (AUCs) for significant CAD using minimal segmental MBF were comparable between automatic and manual MC (AUC = 0.877 automatic, AUC = 0.888 Reader 1 and AUC = 0.892 Reader 2; all P > 0.05). AUCs of minimal segmental MBF with manual and automatic MC were significantly higher than without MC (P < 0.05 for both). Similar findings were observed with minimal segmental MFR.

conclusionsAutomatic MC can be performed rapidly, with diagnostic performance for predicting obstructive CAD comparable to manual MC. This method could be utilized for analysis of MBF/MFR in patients undergoing

Indexed as

AminopyridinesCoronary Artery DiseaseCoronary CirculationMyocardial Perfusion ImagingPositron-Emission TomographyPyridazinesAgedAlgorithmsCoronary AngiographyFemaleHumansMaleMiddle AgedMotionRadiopharmaceuticalsReproducibility of ResultsAminopyridinesBMS 747158-02PyridazinesRadiopharmaceuticals(18)F-flurpiridazMotion correctionMyocardial blood flowMyocardial flow reserveMyocardial perfusion imagingPET

Identifiers

PMID39510243
PMCPMC12173448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.