Evidence map›Paper›PMID 39509806›Full record

ArticleHormones and behavior2024

Chronic high-dose testosterone disrupts social cognition and enhances social dominance in male long-Evans rats.

Jay Wenner, Ruth I Wood

Abstract read
In one paragraph

Article in Hormones and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jay WennerDepartment of Biological Sciences, University of Southern California, Los Angeles, CA 90033, United States of America.
Ruth I WoodDepartment of Integrative Anatomical Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, United States of America. Electronic address: riw@usc.edu.

Funding

Anabolic-androgenic steroids promote risky decision makingR01DA029613 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAKOWEC, MICHAEL WALTER, WOOD, RUTH I. · 2011 to 2019
$2.9M
NIDA NIH HHS R01 DA029613
6 · The paper itself

Abstract

While increased aggression is the most consistent behavioral effect of anabolic androgenic steroid (AAS) abuse, its cause remains unclear. AAS may promote aggression by disrupting social behaviors which maintain dominance hierarchies. To model AAS abuse, we treated male rats with chronic high-dose testosterone and tested social recognition, social learning, and competitive and aggressive dominance. Rats received daily injections s.c. of testosterone (7.5 mg/kg) or vehicle (n = 8/group). We tested social recognition by measuring investigation of a novel or familiar stimulus animal, social learning with the social transmission of food preference (STFP) test, aggressive dominance with the tube test, and competitive dominance with a food competition task. For social recognition, testosterone-treated rats did not prefer the novel stimulus rat (72.8 ± 9.3 s) over the familiar rat (68.8 ± 8.0 s, N.S.) rat. In the STFP test, testosterone-treated rats did not show a significant preference for the demonstrated flavor (59.9 ± 9.4 %, N.S.) compared with controls (70.1 ± 5.4 %, p < 0.05). In the tube test, testosterone did not increase the number of rounds won. However, when the testosterone-treated rat won, they were more likely to be lighter than their vehicle-treated opponent, χ

Indexed as

AggressionRats, Long-EvansSocial DominanceTestosteroneAndrogensAnimalsFood PreferencesMaleRatsRecognition, PsychologySocial BehaviorSocial CognitionSocial LearningAndrogensTestosteroneAggressive dominanceCompetitive dominanceSocial learningSocial recognition

Identifiers

PMID39509806
PMCPMC11602337

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.